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CCT8 [cytosol]
Stable Identifier
R-HSA-390449
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
T-complex protein 1 subunit theta (TCP-1-theta)
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Association of TriC/CCT with target proteins during biosynthesis (Homo sapiens)
Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
CCT/TRiC:substrate complex [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
CCT/TRiC:ADP:Sphingosine kinase 1 [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
ATP binds G-protein beta associated TRiC/CCT (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
PDCL binds G-protein beta and TRiC/CCT (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
PDCL promotes G-protein beta 5 folding (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
PDCL releases folded G-beta from TRiC/CCT (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
RGS proteins bind GNB5 and CCT/TRiC (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP [plasma membrane] (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
Release of GNB5:RGS dimers from CCT/TRiC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP [plasma membrane] (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
TRiC/CCT binds unfolded G-protein beta subunit (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (Homo sapiens)
Folding of actin by CCT/TriC (Homo sapiens)
Exchange of ADP for ATP in CCT/TriC:actin complex (Homo sapiens)
CCT/TRiC:ADP:actin [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
CCT/TRiC:ATP:actin [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
Hydrolysis of ATP and release of folded actin from CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
CCT/TRiC:ATP:actin [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
Formation of tubulin folding intermediates by CCT/TriC (Homo sapiens)
ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex (Homo sapiens)
CCT/TRiC:ADP:non-native tubulin [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
Prefoldin mediated transfer of substrate to CCT/TriC (Homo sapiens)
Actin/tubulin:prefoldin complex associates with CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
actin/tubulin-bound CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
BBSome-mediated cargo-targeting to cilium (Homo sapiens)
Formation of the BBSome (Homo sapiens)
BBS/CCT complex [cytosol] (Homo sapiens)
CCT8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P50990 CCT8
Gene Names
CCT8, C21orf112, CCTQ, KIAA0002
Chain
initiator methionine:1, chain:2-548
Reference Genes
BioGPS Gene:10694 CCT8
COSMIC (genes):CCT8 CCT8
CTD Gene:10694 CCT8
dbSNP Gene:10694 CCT8
ENSEMBL:ENSG00000156261 CCT8
HGNC:1623 CCT8
KEGG Gene (Homo sapiens):10694 CCT8
Monarch:10694 CCT8
NCBI Gene:10694 CCT8
OMIM:617786 CCT8
UCSC:P50990 CCT8
Reference Transcript
RefSeq:NM_001282907.1 CCT8
RefSeq:NM_006585.3 CCT8
RefSeq:NM_001282909.1 CCT8
Other Identifiers
0003440070
10694
11733131_s_at
11752550_x_at
11756850_x_at
11757031_a_at
16924719
200873_s_at
2433265
2433269
2433271
2433273
3928072
3928073
3928076
3928077
3928078
3928079
3928081
3928083
3928085
3928087
3928089
3928091
3928093
3928094
3928095
3928097
3928102
3928103
3928104
3928105
39767_at
8069753
A_23_P102876
D13627_at
GE57061
GO:0000003
GO:0000166
GO:0002199
GO:0002376
GO:0003674
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005764
GO:0005773
GO:0005813
GO:0005815
GO:0005829
GO:0005832
GO:0005856
GO:0005874
GO:0005929
GO:0006259
GO:0006457
GO:0006810
GO:0007339
GO:0008150
GO:0009058
GO:0016192
GO:0016887
GO:0022607
GO:0031410
GO:0032212
GO:0032991
GO:0034641
GO:0034774
GO:0035578
GO:0042592
GO:0042995
GO:0043167
GO:0043226
GO:0043312
GO:0044297
GO:0045111
GO:0045296
GO:0046931
GO:0050821
GO:0051082
GO:0051276
GO:0065003
GO:0070062
GO:1901998
GO:1904813
GO:1904851
GO:1904871
GO:1904874
ILMN_1717868
TC21000353.hg
g6005726_3p_a_at
Participant Of
hasComponent
BBS/CCT complex [cytosol]
CCT/TRiC:ADP [cytosol]
CCT/TriC:ATP [cytosol]
CCT/TRiC:ATP:unfolded tubulin complex [cytosol]
Other forms of this molecule
CCT8 [secretory granule lumen]
CCT8 [extracellular region]
CCT8 [ficolin-1-rich granule lumen]
CCT8 [azurophil granule lumen]
Inferred To
Ghost homologue of CCT8 [cytosol] (Gallus gallus)
cct-8 [cytosol] (Caenorhabditis elegans)
Cct8 [cytosol] (Mus musculus)
Cct8 [cytosol] (Rattus norvegicus)
CCT8 [cytosol] (Canis familiaris)
CCT8 [cytosol] (Drosophila melanogaster)
CCT8 [cytosol] (Plasmodium falciparum)
CCT8 [cytosol] (Saccharomyces cerevisiae)
CCT8 [cytosol] (Sus scrofa)
cct8 [cytosol] (Danio rerio)
cct8 [cytosol] (Dictyostelium discoideum)
cct8 [cytosol] (Schizosaccharomyces pombe)
cct8 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_001269838.1
,
NP_001269836.1
,
NP_006576.2
Target Pathogen
5b354852be737e166372e7c3
OpenTargets
ENSG00000156261
HPA
ENSG00000156261-CCT8
GeneCards
P50990
Ensembl
ENSP00000486921
,
ENSP00000442730
,
ENSG00000156261
,
ENSP00000286788
,
ENST00000286788
,
ENST00000540844
,
ENST00000626972
PRO
P50990
PDB
6NRA
,
6NRD
,
6NR8
,
6QB8
,
6NR9
,
6NRC
,
6NRB
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
4
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.643
3
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.564
2
UniProt:Q13547 HDAC1
2
SUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
HDAC1 [nucleoplasm]
(R-HSA-205021)
0.527
3
UniProt:P04049 RAF1
54
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
RAF1 [cytosol]
(R-HSA-167205)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
p-S621-RAF1 G361A [cytosol]
(R-HSA-9656092)
p-S621-RAF1 G370R [cytosol]
(R-HSA-9656094)
p-S621-RAF1 D486G [cytosol]
(R-HSA-9656085)
p-S621-RAF1 T491R [cytosol]
(R-HSA-9656145)
p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]
(R-HSA-9656026)
p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]
(R-HSA-9656070)
p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]
(R-HSA-9656035)
p-S338,Y341,S494,S621-RAF1 T491I [cytosol]
(R-HSA-9656019)
p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]
(R-HSA-9656029)
p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]
(R-HSA-9656031)
p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]
(R-HSA-9656023)
p-S338,Y341,S494,S621 RAF1 T491R [cytosol]
(R-HSA-9656017)
p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]
(R-HSA-9656062)
p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]
(R-HSA-9656041)
p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]
(R-HSA-9656058)
p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]
(R-HSA-9656043)
p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]
(R-HSA-9656053)
p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]
(R-HSA-9656037)
p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]
(R-HSA-9656050)
p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]
(R-HSA-9656067)
p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]
(R-HSA-9656077)
p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]
(R-HSA-9656047)
p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]
(R-HSA-9656056)
p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]
(R-HSA-9656074)
p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]
(R-HSA-9656080)
p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]
(R-HSA-9656065)
hyperphosphorylated RAF1 [plasma membrane]
(R-HSA-5675193)
p-S621-RAF1 [plasma membrane]
(R-HSA-206222)
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5675420)
p-S259,S621-RAF1 [cytosol]
(R-HSA-109786)
p-S621-RAF1 [cytosol]
(R-HSA-206028)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5672665)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-HSA-5672664)
0.527
3
UniProt:Q13882 PTK6
5
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
PTK6 [cytosol]
(R-HSA-8848000)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
0.527
3
UniProt:O43815 STRN
3
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
STRN [cytosol]
(R-HSA-9037081)
p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
0.527
2
UniProt:P52333 JAK3
5
JAK3 [endosome]
(R-HSA-8983184)
p-Y904,939-JAK3 [plasma membrane]
(R-HSA-8985978)
p-JAK3 [cytosol]
(R-HSA-8982856)
p-Y-JAK3 [cytosol]
(R-HSA-9006854)
JAK3 [cytosol]
(R-HSA-451893)
0.527
2
UniProt:Q00535 CDK5
4
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
CDK5 [nucleoplasm]
(R-HSA-8863586)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
0.527
2
UniProt:Q9BUR4 WRAP53
2
Unfolded WRAP53 [cytosol]
(R-HSA-6813830)
WRAP53 [nucleoplasm]
(R-HSA-418386)
0.527
2
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