Reactome | CCT8 [cytosol]

CCT8 [cytosol]

Stable Identifier

R-HSA-390449

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit theta (TCP-1-theta)

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - BBSome-mediated cargo-targeting to cilium (Homo sapiens)
      - Formation of the BBSome (Homo sapiens)
        
        BBS/CCT complex [cytosol] (Homo sapiens)
        
        CCT8 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P50990 CCT8

Gene Names

CCT8, C21orf112, CCTQ, KIAA0002

Chain

initiator methionine:, chain:2-548

Reference Genes

BioGPS Gene:10694 CCT8

COSMIC (genes):CCT8 CCT8

CTD Gene:10694 CCT8

dbSNP Gene:10694 CCT8

ENSEMBL:ENSG00000156261 CCT8

HGNC:1623 CCT8

KEGG:hsa:10694 CCT8

Monarch:10694 CCT8

NCBI Gene:10694 CCT8

OMIM:617786 CCT8

UCSC:P50990 CCT8

Reference Transcript

Other Identifiers

10694

11733131_s_at

11752550_x_at

11756850_x_at

11757031_a_at

16924719

200873_PM_s_at

200873_s_at

2433265

2433269

2433271

2433273

3928071

3928072

3928073

3928076

3928077

3928078

3928079

3928080

3928081

3928082

3928083

3928084

3928085

3928086

3928087

3928088

3928089

3928090

3928091

3928092

3928093

3928094

3928095

3928097

3928099

3928101

3928102

3928103

3928104

3928105

39767_at

8069753

A_23_P102876

D13627_at

GE57061

GO:0002199

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0005929

GO:0006457

GO:0007339

GO:0016787

GO:0016887

GO:0032212

GO:0034774

GO:0035578

GO:0042995

GO:0043226

GO:0044183

GO:0044297

GO:0045111

GO:0045296

GO:0050821

GO:0051082

GO:0051086

GO:0061077

GO:0070062

GO:0140657

GO:0140662

GO:1904813

GO:1904871

GO:1904874

HMNXSV003027142

HMNXSV003041563

ILMN_1717868

PH_hs_0025044

TC21000353.hg

g13528842_3p_at

g6005726_3p_a_at

Participates

as a component of

Other forms of this molecule

CCT8 [ficolin-1-rich granule lumen]

CCT8 [extracellular region]

CCT8 [secretory granule lumen]

CCT8 [azurophil granule lumen]

Inferred To

Ghost homologue of CCT8 [cytosol] (Danio rerio)

cct-8 [cytosol] (Caenorhabditis elegans)

Cct8 [cytosol] (Mus musculus)

Cct8 [cytosol] (Rattus norvegicus)

CCT8 [cytosol] (Bos taurus)

CCT8 [cytosol] (Canis familiaris)

CCT8 [cytosol] (Drosophila melanogaster)

CCT8 [cytosol] (Gallus gallus)

CCT8 [cytosol] (Plasmodium falciparum)

CCT8 [cytosol] (Saccharomyces cerevisiae)

CCT8 [cytosol] (Sus scrofa)

cct8 [cytosol] (Dictyostelium discoideum)

cct8 [cytosol] (Schizosaccharomyces pombe)

cct8 [cytosol] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000156261

ENSEMBL

ENST00000540844, ENST00000286788, ENST00000707892, ENST00000707884, ENSP00000486921, ENST00000707885, ENSP00000286788, ENST00000626972, ENSP00000442730, ENSP00000517020, ENSP00000517017, ENSG00000156261, ENSG00000291533, ENSP00000517018

HPA

ENSG00000156261-CCT8

GeneCards

CCT8

PRO

P50990

Pharos - Targets

P50990

GlyGen

P50990

PDB

6NRB, 8SHN, 8SHO, 7TTT, 7NVN, 7TRG, 8SHT, 8SHQ, 7NVM, 8I9U, 8IB8, 7WZ3, 8SFE, 8I1U, 8SGQ, 7TUB, 7X7Y, 6NR9, 7LUM, 8SHE, 7X0A, 8SHL, 8SHD, 8SG8, 7X3J, 7TTN, 6NRC, 8SHP, 7WU7, 7NVL, 7NVO, 8HKI, 7X0V, 7X0S, 6NRA, 6NRD, 7X6Q, 8SFF, 6QB8, 7X3U, 8SGL, 6NR8, 8SHA, 8SHF, 8SHG, 7LUP, 8SH9, 8SG9, 8SGC

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.725	4
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.725	4
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.669	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:Q00535 CDK5	4	CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586)	0.643	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.643	4
UniProt:P04049 RAF1	20	p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094)	0.643	7
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	19
UniProt:Q13882 PTK6	5	PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937)	0.527	3
UniProt:P52333 JAK3	6	JAK3 [cytosol] (R-HSA-451893) p-Y-JAK3 [cytosol] (R-HSA-9006854) p-JAK3 [cytosol] (R-HSA-8982856) JAK3 [endosome] (R-HSA-8983184) p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978) p-Y980 JAK3 [cytosol] (R-HSA-9701438)	0.527	2
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:O00628 PEX7	2	PEX7 [peroxisomal membrane] (R-HSA-9033493) PEX7 [cytosol] (R-HSA-9033107)	0.527	3
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.527	2

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