Reactome | CCT8 [cytosol]

CCT8 [cytosol]

Stable Identifier

R-HSA-390449

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit theta (TCP-1-theta)

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - BBSome-mediated cargo-targeting to cilium (Homo sapiens)
      - Formation of the BBSome (Homo sapiens)
        
        BBS/CCT complex [cytosol] (Homo sapiens)
        
        CCT8 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P50990 CCT8

Gene Names

CCT8, C21orf112, CCTQ, KIAA0002

Chain

initiator methionine:1, chain:2-548

Reference Genes

BioGPS Gene:10694 CCT8

COSMIC (genes):CCT8 CCT8

CTD Gene:10694 CCT8

dbSNP Gene:10694 CCT8

ENSEMBL:ENSG00000156261 CCT8

HGNC:1623 CCT8

KEGG Gene (Homo sapiens):10694 CCT8

Monarch:10694 CCT8

NCBI Gene:10694 CCT8

OMIM:617786 CCT8

UCSC:P50990 CCT8

Reference Transcript

Other Identifiers

0003440070

10694

11733131_s_at

11752550_x_at

11756850_x_at

11757031_a_at

16924719

200873_s_at

2433265

2433269

2433271

2433273

3928072

3928073

3928076

3928077

3928078

3928079

3928081

3928083

3928085

3928087

3928089

3928091

3928093

3928094

3928095

3928097

3928102

3928103

3928104

3928105

39767_at

8069753

A_23_P102876

D13627_at

GE57061

GO:0000003

GO:0000166

GO:0002199

GO:0002376

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005764

GO:0005773

GO:0005813

GO:0005815

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0005929

GO:0006259

GO:0006457

GO:0006810

GO:0007339

GO:0008150

GO:0009058

GO:0016192

GO:0016887

GO:0022607

GO:0031410

GO:0032212

GO:0032991

GO:0034641

GO:0034774

GO:0035578

GO:0042592

GO:0042995

GO:0043167

GO:0043226

GO:0043312

GO:0044297

GO:0045111

GO:0045296

GO:0046931

GO:0050821

GO:0051082

GO:0051276

GO:0065003

GO:0070062

GO:1901998

GO:1904813

GO:1904851

GO:1904871

GO:1904874

ILMN_1717868

TC21000353.hg

g6005726_3p_a_at

Participant Of

hasComponent

Other forms of this molecule

CCT8 [secretory granule lumen]

CCT8 [extracellular region]

CCT8 [ficolin-1-rich granule lumen]

CCT8 [azurophil granule lumen]

Inferred To

Ghost homologue of CCT8 [cytosol] (Gallus gallus)

cct-8 [cytosol] (Caenorhabditis elegans)

Cct8 [cytosol] (Mus musculus)

Cct8 [cytosol] (Rattus norvegicus)

CCT8 [cytosol] (Canis familiaris)

CCT8 [cytosol] (Drosophila melanogaster)

CCT8 [cytosol] (Plasmodium falciparum)

CCT8 [cytosol] (Saccharomyces cerevisiae)

CCT8 [cytosol] (Sus scrofa)

cct8 [cytosol] (Danio rerio)

cct8 [cytosol] (Dictyostelium discoideum)

cct8 [cytosol] (Schizosaccharomyces pombe)

cct8 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001269838.1, NP_001269836.1, NP_006576.2

Target Pathogen

5b354852be737e166372e7c3

OpenTargets

ENSG00000156261

HPA

ENSG00000156261-CCT8

GeneCards

P50990

Ensembl

ENSP00000486921, ENSP00000442730, ENSG00000156261, ENSP00000286788, ENST00000286788, ENST00000540844, ENST00000626972

PRO

P50990

PDB

6NRA, 6NRD, 6NR8, 6QB8, 6NR9, 6NRC, 6NRB

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.643	3
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.564	2
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.527	3
UniProt:P04049 RAF1	54	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.527	3
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) PTK6 [cytosol] (R-HSA-8848000) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103)	0.527	3
UniProt:O43815 STRN	3	STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) STRN [cytosol] (R-HSA-9037081) p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908)	0.527	2
UniProt:P52333 JAK3	5	JAK3 [endosome] (R-HSA-8983184) p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978) p-JAK3 [cytosol] (R-HSA-8982856) p-Y-JAK3 [cytosol] (R-HSA-9006854) JAK3 [cytosol] (R-HSA-451893)	0.527	2
UniProt:Q00535 CDK5	4	p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [nucleoplasm] (R-HSA-8863586) CDK5 [cytosol] (R-HSA-180064) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249)	0.527	2
UniProt:Q9BUR4 WRAP53	2	Unfolded WRAP53 [cytosol] (R-HSA-6813830) WRAP53 [nucleoplasm] (R-HSA-418386)	0.527	2

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