Reactome | CCT7 [cytosol]

CCT7 [cytosol]

Stable Identifier

R-HSA-390451

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit eta (TCP-1-eta)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q99832 CCT7

Gene Names

CCT7, CCTH, NIP7-1

Chain

chain:1-543, initiator methionine:, chain:2-543

Reference Genes

BioGPS Gene:10574 CCT7

COSMIC (genes):CCT7 CCT7

CTD Gene:10574 CCT7

dbSNP Gene:10574 CCT7

ENSEMBL:ENSG00000135624 CCT7

HGNC:1622 CCT7

KEGG:hsa:10574 CCT7

Monarch:10574 CCT7

NCBI Gene:10574 CCT7

OMIM:605140 CCT7

UCSC:Q99832 CCT7

Reference Transcript

Other Identifiers

10574

11737913_s_at

16881485

200812_PM_at

200812_at

2488733

2488734

2488735

2488736

2488737

2488738

2488739

2488740

2488741

2488742

2488743

2488746

2488747

2488748

2488749

2488750

2488753

2488754

38720_at

8042720

A_14_P137418

A_23_P102404

GE54204

GO:0003824

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005832

GO:0005874

GO:0006457

GO:0007339

GO:0016787

GO:0016887

GO:0032212

GO:0042026

GO:0043226

GO:0044183

GO:0044297

GO:0050821

GO:0051082

GO:0051086

GO:0061077

GO:0070062

GO:0140657

GO:0140662

GO:1904871

GO:1904874

HMNXSV003006334

ILMN_1662954

ILMN_1703718

ILMN_2341793

PH_hs_0024059

PH_hs_0032888

TC02000440.hg

TC02003327.hg

U83843_at

g5453606_3p_at

Participates

as a candidate of

as a component of

Inferred To

cct-7 [cytosol] (Caenorhabditis elegans)

cct7 [cytosol] (Danio rerio)

cct7 [cytosol] (Dictyostelium discoideum)

cct7 [cytosol] (Schizosaccharomyces pombe)

cct7 [cytosol] (Xenopus tropicalis)

CCT7 [cytosol] (Bos taurus)

CCT7 [cytosol] (Drosophila melanogaster)

CCT7 [cytosol] (Gallus gallus)

CCT7 [cytosol] (Plasmodium falciparum)

CCT7 [cytosol] (Saccharomyces cerevisiae)

CCT7 [cytosol] (Sus scrofa)

Cct7 [cytosol] (Mus musculus)

Cct7 [cytosol] (Rattus norvegicus)

LOC100856782 [cytosol] (Canis familiaris)

Cross References

OpenTargets

ENSG00000135624

ENSEMBL

ENSP00000437824, ENSP00000258091, ENST00000540468, ENST00000398422, ENST00000539919, ENSP00000381456, ENST00000258091, ENSP00000442058

HPA

ENSG00000135624-CCT7

PRO

Q99832

Pharos - Targets

Q99832

GlyGen

Q99832

PDB

8SFF, 8SGL, 7X6Q, 7X0S, 6NRA, 7X0V, 6NRD, 8HKI, 7NVO, 7NVL, 7WU7, 6NRC, 8SHP, 7X3J, 7TTN, 8SG9, 8SHG, 8SHF, 8SHA, 6NR8, 7X3U, 7LUP, 8SH9, 6QB8, 8I1U, 8SFE, 7WZ3, 7NVM, 8SHQ, 8IB8, 7NVN, 8SHT, 8I9U, 7TRG, 7TTT, 8SHO, 6NRB, 8SHN, 8SGC, 8SG8, 8SHL, 8SHE, 7X0A, 7LUM, 8SHD, 6NR9, 7X7Y, 7TUB, 8SGQ

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.788	5
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.725	5
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.725	4
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.725	6
UniProt:Q13371 PDCL	2	p-S18,S19,S20,S25-PDCL [cytosol] (R-HSA-6814228) PDCL [cytosol] (R-HSA-6813727)	0.643	4
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.643	3
UniProt:Q92466 DDB2	3	DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654) PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035)	0.643	4
UniProt:Q00535 CDK5	4	p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586)	0.643	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	7
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.527	3
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.527	2
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.527	6
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:Q9Y5J1 UTP18	1	UTP18 [nucleoplasm] (R-HSA-6790645)	0.527	2
UniProt:O94953 KDM4B	2	K48PolyUb-KDM4B [nucleoplasm] (R-HSA-5683074) KDM4B [nucleoplasm] (R-HSA-3214396)	0.527	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	2
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.527	2
UniProt:O00628 PEX7	2	PEX7 [peroxisomal membrane] (R-HSA-9033493) PEX7 [cytosol] (R-HSA-9033107)	0.527	3
UniProt:Q9BQA1 WDR77	3	WDR77 [cytosol] (R-HSA-191823) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [nucleoplasm] (R-HSA-5205610)	0.527	3
UniProt:Q9NW82 WDR70	1	WDR70 [nucleoplasm] (R-HSA-9770425)	0.527	2
UniProt:O60508 CDC40	1	CDC40 [nucleoplasm] (R-HSA-72062)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9

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