Reactome | Unfolded ACTB [cytosol]

Unfolded ACTB [cytosol]

Stable Identifier

R-HSA-390462

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ACTB, Unfolded beta-actin

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P60709 ACTB

Gene Names

ACTB

Chain

initiator methionine:1, chain:1-375, chain:2-375

Reference Genes

BioGPS Gene:60 ACTB

COSMIC (genes):ACTB ACTB

CTD Gene:60 ACTB

dbSNP Gene:60 ACTB

ENSEMBL:ENSG00000075624 ACTB

HGNC:132 ACTB

KEGG Gene (Homo sapiens):60 ACTB

Monarch:60 ACTB

NCBI Gene:60 ACTB

OMIM:102630 ACTB

Reference Transcript

RefSeq:NM_001101.3 ACTB

Other Identifiers

0000110022

0000430039

11720754_x_at

11752865_x_at

11756071_x_at

200801_x_at

213867_x_at

224594_x_at

2419182

2457900

2457901

2816906

2816908

2963900

3036925

3036926

3036927

3036928

3036930

3036933

3036934

3036935

3036937

3036938

3036939

3036940

3036944

3036945

32318_s_at

3712504

3975446

64355_s_at

8137979

AFFX-HSAC07/X00351_3_at

AFFX-HSAC07/X00351_5_at

AFFX-HSAC07/X00351_M_at

A_23_P135769

A_23_P31323

A_24_P226554

GE545663

GO:0000079

GO:0000166

GO:0000228

GO:0000790

GO:0000902

GO:0000978

GO:0001738

GO:0001895

GO:0002376

GO:0003674

GO:0003677

GO:0005198

GO:0005200

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005911

GO:0005912

GO:0005925

GO:0006464

GO:0006810

GO:0006950

GO:0007010

GO:0007049

GO:0007155

GO:0007163

GO:0007165

GO:0007409

GO:0008092

GO:0008134

GO:0008150

GO:0015629

GO:0016020

GO:0016192

GO:0016579

GO:0019894

GO:0019899

GO:0019901

GO:0021762

GO:0022607

GO:0022898

GO:0030027

GO:0030154

GO:0030424

GO:0030863

GO:0030957

GO:0031492

GO:0031982

GO:0032091

GO:0032991

GO:0034329

GO:0034330

GO:0034333

GO:0035267

GO:0036464

GO:0038096

GO:0040011

GO:0042592

GO:0042802

GO:0043044

GO:0043167

GO:0043226

GO:0043296

GO:0044305

GO:0045176

GO:0045202

GO:0045815

GO:0048013

GO:0048156

GO:0048488

GO:0048856

GO:0048870

GO:0050998

GO:0051276

GO:0051621

GO:0051623

GO:0055085

GO:0061024

GO:0070062

GO:0070160

GO:0070527

GO:0071896

GO:0072562

GO:0072749

GO:0097433

GO:0098685

GO:0098793

GO:0098871

GO:0098973

GO:0098974

GO:0098978

GO:0150111

GO:1903076

GO:1990904

Hs.288061.2.A1_3p_s_at

ILMN_1343294

ILMN_1777296

ILMN_2038777

ILMN_2152131

M10277_s_at

PH_hs_0030148

TC07001120.hg

TC07002772.hg

TC07002773.hg

X00351_f_at

g12408251_3p_s_at

g5016088_3p_x_at

Participant Of

hasComponent

hasMember

unfolded actin/tubulin [cytosol]

Other forms of this molecule

ACTB(1-375) [plasma membrane]

ACTB(1-375) [cytosol]

ACTB(1-375) [nucleoplasm]

ACTB(1-375) [lysosomal membrane]

Cross References

RefSeq

NP_001092.1

OpenTargets

ENSG00000075624

GeneCards

P60709

HPA

ENSG00000075624-ACTB

Ensembl

ENST00000646664, ENSP00000494269, ENSG00000075624, ENSP00000494750, ENST00000493945

PRO

P60709

Orphanet

17409

PDB

6OX5, 6MBL, 3J82, 6OX1, 3D2U, 6OX0, 6MBK, 3LUE, 3BYH, 6MBJ, 6ICV, 6ANU, 6OX4, 6ICT, 6OX2

Interactors (45)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60709 ACTB	5	ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [plasma membrane] (R-HSA-196016) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [lysosomal membrane] (R-HSA-196160)	0.955	16
UniProt:P63261 ACTG1	3	ACTG1 [cytosol] (R-HSA-201858) ACTG1 [plasma membrane] (R-HSA-196044) ACTG1 [lysosomal membrane] (R-HSA-196169)	0.951	16
UniProt:Q9Y281 COF2			0.881	10
UniProt:P60981 DEST			0.87	9
UniProt:P23528 CFL1	3	p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [cytosol] (R-HSA-350751) CFL1 [extracellular region] (R-HSA-350747)	0.87	9
UniProt:Q96HA8 NTAQ1			0.742	6
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.723	6
UniProt:P40123 CAP2	1	CAP2 [cytosol] (R-HSA-428863)	0.697	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.669	5
UniProt:Q8WTR2 DUS19			0.666	4
UniProt:Q08426 EHHADH	2	EHHADH [cytosol] (R-HSA-9033147) EHHADH [peroxisomal matrix] (R-HSA-400155)	0.666	4
UniProt:P08413 Camk2b	7	phospho-Camk2b [nucleoplasm] (R-RNO-444787) phospho-Camk2b [plasma membrane] (R-RNO-432791) phospho-Camk2b [endocytic vesicle membrane] (R-RNO-417009) Camk2b [cytosol] (R-RNO-9611391) p-T287-Camk2b [cytosol] (R-RNO-9618634) Camk2b [cytosol] (R-RNO-9611360) phospho-Camk2b [cytosol] (R-RNO-445371)	0.615	4
UniProt:Q92731 ESR2	5	PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.597	6
UniProt:P07737 PFN1	2	PFN1 [cytosol] (R-HSA-203081) PFN1 [extracellular region] (R-HSA-350755)	0.592	2
UniProt:P11142 HSPA8	10	HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.573	2
UniProt:P13693 TCTP			0.567	4
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	3
UniProt:P14598 NCF1	4	p-S345-NCF1 [cytosol] (R-HSA-9626824) p-6S-NCF1 [cytosol] (R-HSA-9626854) p-6S-NCF1 [phagolysosome] (R-HSA-1996220) NCF1 [cytosol] (R-HSA-1222296)	0.558	3
UniProt:Q02821	2	SRP1 [cytosol] (R-SCE-205976) SRP1 [cytosol] (R-SCE-180612)	0.556	3
UniProt:P46680	2	AIP1 [cytosol] (R-SCE-350699) AIP1 [extracellular region] (R-SCE-350752)	0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.556	3
UniProt:P60010 ACT			0.556	3
UniProt:P78317 RNF4	2	RNF4 [cytosol] (R-HSA-975974) RNF4 [nucleoplasm] (R-HSA-5684076)	0.556	3
UniProt:Q549N0 Q549N0			0.556	3
UniProt:Q9PTD7 CING			0.544	2
UniProt:O14950 MYL12B	3	MYL12B [cytosol] (R-HSA-390727) p-T19-MYL12B [cytosol] (R-HSA-5668936) p-T19,S20-MYL12B [cytosol] (R-HSA-390751)	0.537	3
UniProt:P83110 HTRA3			0.537	5
UniProt:P04626 ERBB2	117	ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-6Y-ERBB2 E693K [plasma membrane] (R-HSA-9665871) p-6Y-ERBB2 R677L [plasma membrane] (R-HSA-9665864) p-6Y-ERBB2 Q709L [plasma membrane] (R-HSA-9665865) p-6Y-ERBB2 G660D [plasma membrane] (R-HSA-9665866) p-6Y-ERBB2 G660R [plasma membrane] (R-HSA-9665878) p-6Y-ERBB2 V659K [plasma membrane] (R-HSA-9665863) p-6Y-ERBB2 V659E [plasma membrane] (R-HSA-9665874) ERBB2 R678Q [plasma membrane] (R-HSA-9665756) ERBB2 S653C [plasma membrane] (R-HSA-9665754) ERBB2 R677L [plasma membrane] (R-HSA-9665759) ERBB2 G660R [plasma membrane] (R-HSA-9665768) ERBB2 V659E [plasma membrane] (R-HSA-9665752) ERBB2 G660D [plasma membrane] (R-HSA-9665753) ERBB2 V659K [plasma membrane] (R-HSA-9665769) ERBB2 Q709L [plasma membrane] (R-HSA-9665770) ERBB2 E693K [plasma membrane] (R-HSA-9665761) p-6Y-ERBB2 R678Q [plasma membrane] (R-HSA-9665876) p-6Y-ERBB2 S653C [plasma membrane] (R-HSA-9665875) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) ERBB2 [plasma membrane] (R-HSA-372889) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.537	10
UniProt:P06213-PRO_0000016689 INSR			0.527	3
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.527	2
UniProt:P10636-8 MAPT	2	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	2
UniProt:P50402 EMD	3	EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [nuclear envelope] (R-HSA-201573)	0.524	2
UniProt:P83110-2 HTRA3			0.512	3
UniProt:Q9WMX2-PRO_0000037551			0.508	3
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2
UniProt:Q92636 NSMAF	1	NSMAF [cytosol] (R-HSA-5626992)	0.499	2
IntAct:EBI-6863782 NS3			0.499	2
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.491	2
UniProt:P11275 Camk2a	6	phospho-Camk2a [nucleoplasm] (R-RNO-444797) phospho-Camk2a [plasma membrane] (R-RNO-432796) phospho-Camk2a [endocytic vesicle membrane] (R-RNO-416999) phospho-Camk2a [cytosol] (R-RNO-4332334) Camk2a [cytosol] (R-RNO-9611390) p-T286-Camk2a [cytosol] (R-RNO-9618632)	0.488	2
UniProt:Q8TCJ0 FBX25			0.463	2
UniProt:P46092 CCR10	1	CCR10 [plasma membrane] (R-HSA-373126)	0.463	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2

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