Reactome | CCT3 [cytosol]

CCT3 [cytosol]

Stable Identifier

R-HSA-390463

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit gamma (TCP-1-gamma)

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - BBSome-mediated cargo-targeting to cilium (Homo sapiens)
      - Formation of the BBSome (Homo sapiens)
        
        BBS/CCT complex [cytosol] (Homo sapiens)
        
        CCT3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49368 CCT3

Gene Names

CCT3, CCTG, TRIC5

Chain

chain:1-545

Reference Genes

BioGPS Gene:7203 CCT3

COSMIC (genes):CCT3 CCT3

CTD Gene:7203 CCT3

dbSNP Gene:7203 CCT3

ENSEMBL:ENSG00000163468 CCT3

HGNC:1616 CCT3

KEGG Gene (Homo sapiens):7203 CCT3

Monarch:7203 CCT3

NCBI Gene:7203 CCT3

OMIM:600114 CCT3

UCSC:P49368 CCT3

Reference Transcript

Other Identifiers

0003360575

11716382_a_at

11716383_x_at

11750144_x_at

11750432_a_at

11750433_x_at

16694529

200910_at

2438126

2438127

2438128

2438129

2438131

2438133

2438134

2438136

2438137

2438138

2438139

2438146

2438147

2438148

2438150

2438157

2438158

2438159

2438160

2438161

40774_at

6543

7203

7920984

A_23_P160631

AAC50068

AAH06501

AAH08019

AK293477

AL589685

AL833197

B4DUR8

BAG56968

BC006501

BC008019

CAA52808

CAI46192

CCDS1140

CCDS30888

CCT3

CCT3-201

CCT3-204

E9PM09

E9PQ35

E9PRC8

E9PRM9

E9PRN0

ENSG00000163468

ENSP00000295688

ENSP00000357242

ENST00000295688

ENST00000295688.7

ENST00000368259

ENST00000368259.6

EntrezGene:7203

EntrezGene:CCT3

g5174726_3p_at

GE81585

GO:0000003

GO:0000166

GO:0002199

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0005886

GO:0006259

GO:0006457

GO:0006810

GO:0007339

GO:0008150

GO:0009058

GO:0022607

GO:0032212

GO:0032991

GO:0034641

GO:0042592

GO:0043167

GO:0043226

GO:0044297

GO:0046931

GO:0050821

GO:0051082

GO:0051276

GO:0065003

GO:0070062

GO:1901998

GO:1904851

GO:1904871

GO:1904874

HGNC:1616

HPA006543

ILMN_1651828

ILMN_2334989

IPR002194

IPR002423

IPR012719

IPR017998

IPR027409

IPR027410

IPR027413

MIM:600114

NM_001008800

NM_005998

NP_001008800

NP_005989

PF00118

PH_hs_0000233

PR00304

Q5SZW8

Q5SZX6

Q5SZX9

TC01003337.hg

TC01005857.hg

U17104

UPI000040EEFE

UPI00004CA9C3

X74801

X74801_at

Participant Of

hasComponent

Inferred To

Ghost homologue of CCT3 [cytosol] (Sus scrofa)

CCT3 [cytosol] (Bos taurus)

CCT3 [cytosol] (Caenorhabditis elegans)

CCT3 [cytosol] (Canis familiaris)

CCT3 [cytosol] (Danio rerio)

CCT3 [cytosol] (Dictyostelium discoideum)

CCT3 [cytosol] (Drosophila melanogaster)

CCT3 [cytosol] (Gallus gallus)

CCT3 [cytosol] (Mus musculus)

CCT3 [cytosol] (Plasmodium falciparum)

CCT3 [cytosol] (Rattus norvegicus)

CCT3 [cytosol] (Saccharomyces cerevisiae)

CCT3 [cytosol] (Schizosaccharomyces pombe)

CCT3 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_005989.3, NP_001008800.1

OpenTargets

ENSG00000163468

GeneCards

P49368

PRO

P49368

PDB

6NRB, 6NRD, 6QB8, 6NR8, 6NRC, 6NR9, 6NRA

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.643	3
UniProt:Q13371 PDCL	2	p-S18,S19,S20,S25-PDCL [cytosol] (R-HSA-6814228) PDCL [cytosol] (R-HSA-6813727)	0.621	3
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.597	5
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.564	2
UniProt:Q16659 MAPK6	6	MAPK6 [nucleoplasm] (R-HSA-5692686) p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.547	2
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	2
UniProt:Q00535 CDK5	4	CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586)	0.527	2
UniProt:O43815 STRN	1	STRN [cytosol] (R-HSA-9037081)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.527	2
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.488	2
UniProt:Q8IWZ6 BBS7	1	BBS7 [cytosol] (R-HSA-5617632)	0.462	2