Reactome | CCT3 [cytosol]

CCT3 [cytosol]

Stable Identifier

R-HSA-390463

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit gamma (TCP-1-gamma)

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - BBSome-mediated cargo-targeting to cilium (Homo sapiens)
      - Formation of the BBSome (Homo sapiens)
        
        BBS/CCT complex [cytosol] (Homo sapiens)
        
        CCT3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49368 CCT3

Gene Names

CCT3, CCTG, TRIC5

Chain

chain:1-545

Reference Genes

BioGPS Gene:7203 CCT3

COSMIC (genes):CCT3 CCT3

CTD Gene:7203 CCT3

dbSNP Gene:7203 CCT3

ENSEMBL:ENSG00000163468.15 CCT3

HGNC:1616 CCT3

KEGG Gene (Homo sapiens):7203 CCT3

Monarch:7203 CCT3

NCBI Gene:7203 CCT3

OMIM:600114 CCT3

UCSC:P49368 CCT3

Reference Transcript

Other Identifiers

0003360575

11716382_a_at

11716383_x_at

11750144_x_at

11750432_a_at

11750433_x_at

16694529

200910_PM_at

200910_at

2438126

2438127

2438128

2438129

2438131

2438133

2438134

2438136

2438137

2438138

2438139

2438146

2438147

2438148

2438150

2438157

2438158

2438159

2438160

2438161

40774_at

7203

7920984

A_23_P160631

GE81585

GO:0000166

GO:0002199

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0006457

GO:0007339

GO:0008150

GO:0016887

GO:0022414

GO:0032200

GO:0032212

GO:0032991

GO:0043167

GO:0043226

GO:0044183

GO:0044297

GO:0046931

GO:0050821

GO:0051082

GO:0061077

GO:0065003

GO:0070062

GO:0140657

GO:0140662

GO:1901998

GO:1904851

GO:1904871

GO:1904874

HMNXSV003029993

ILMN_1651828

ILMN_2334989

PH_hs_0000233

TC01003337.hg

TC01005857.hg

X74801_at

g5174726_3p_at

Participates

as a component of

Inferred To

Homologues of CCT3 [cytosol] (Gallus gallus)

cct-3 [cytosol] (Caenorhabditis elegans)

cct3 [cytosol] (Dictyostelium discoideum)

cct3 [cytosol] (Schizosaccharomyces pombe)

CCT3 [cytosol] (Bos taurus)

CCT3 [cytosol] (Canis familiaris)

CCT3 [cytosol] (Danio rerio)

CCT3 [cytosol] (Drosophila melanogaster)

CCT3 [cytosol] (Gallus gallus)

CCT3 [cytosol] (Plasmodium falciparum)

CCT3 [cytosol] (Saccharomyces cerevisiae)

CCT3 [cytosol] (Sus scrofa)

nat10 [cytosol] (Xenopus tropicalis)

Cct3 [cytosol] (Mus musculus)

Cct3 [cytosol] (Rattus norvegicus)

LOC101751456 [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_001008800.1, NP_005989.3

OpenTargets

ENSG00000163468

HPA

ENSG00000163468-CCT3

GeneCards

P49368

Ensembl

ENSP00000357242, ENSG00000163468, ENSP00000295688, ENST00000368259, ENST00000295688

PRO

P49368

Pharos - Targets

P49368

PDB

7NVN, 6NR9, 7NVM, 6NRD, 7LUP, 6NR8, 7NVL, 6NRC, 6NRA, 7NVO, 6QB8, 7LUM, 6NRB

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.725	4
UniProt:Q13371 PDCL	2	PDCL [cytosol] (R-HSA-6813727) p-S18,S19,S20,S25-PDCL [cytosol] (R-HSA-6814228)	0.666	6
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.643	4
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809)	0.643	3
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.597	5
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.564	2
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.556	3
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) RAF1 [cytosol] (R-HSA-167205) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134)	0.547	5
UniProt:Q16659 MAPK6	6	ub-MAPK6 [cytosol] (R-HSA-5687000) MAPK6 [cytosol] (R-HSA-5686979) p-S189 MAPK6 [cytosol] (R-HSA-5687019) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) MAPK6 [nucleoplasm] (R-HSA-5692686) p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665)	0.547	2
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y342-PTK6 [cytosol] (R-HSA-8848007) PTK6 [cytosol] (R-HSA-8848000) p-Y351-PTK6 [cytosol] (R-HSA-8857570)	0.527	3
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	2
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	6
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q8IWZ6 BBS7	1	BBS7 [cytosol] (R-HSA-5617632)	0.462	2

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