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CCT3 [cytosol]
Stable Identifier
R-HSA-390463
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
T-complex protein 1 subunit gamma (TCP-1-gamma)
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Association of TriC/CCT with target proteins during biosynthesis (Homo sapiens)
Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
CCT/TRiC:substrate complex [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
CCT/TRiC:ADP:Sphingosine kinase 1 [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
ATP binds G-protein beta associated TRiC/CCT (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
PDCL binds G-protein beta and TRiC/CCT (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
PDCL promotes G-protein beta 5 folding (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
PDCL releases folded G-beta from TRiC/CCT (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
RGS proteins bind GNB5 and CCT/TRiC (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP [plasma membrane] (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
Release of GNB5:RGS dimers from CCT/TRiC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP [plasma membrane] (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
TRiC/CCT binds unfolded G-protein beta subunit (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (Homo sapiens)
Folding of actin by CCT/TriC (Homo sapiens)
Exchange of ADP for ATP in CCT/TriC:actin complex (Homo sapiens)
CCT/TRiC:ADP:actin [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
CCT/TRiC:ATP:actin [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
Hydrolysis of ATP and release of folded actin from CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
CCT/TRiC:ATP:actin [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
Formation of tubulin folding intermediates by CCT/TriC (Homo sapiens)
ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex (Homo sapiens)
CCT/TRiC:ADP:non-native tubulin [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
Prefoldin mediated transfer of substrate to CCT/TriC (Homo sapiens)
Actin/tubulin:prefoldin complex associates with CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
actin/tubulin-bound CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
BBSome-mediated cargo-targeting to cilium (Homo sapiens)
Formation of the BBSome (Homo sapiens)
BBS/CCT complex [cytosol] (Homo sapiens)
CCT3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49368 CCT3
Gene Names
CCT3, CCTG, TRIC5
Chain
chain:1-545
Reference Genes
BioGPS Gene:7203 CCT3
COSMIC (genes):CCT3 CCT3
CTD Gene:7203 CCT3
dbSNP Gene:7203 CCT3
ENSEMBL:ENSG00000163468 CCT3
HGNC:1616 CCT3
KEGG Gene (Homo sapiens):7203 CCT3
Monarch:7203 CCT3
NCBI Gene:7203 CCT3
OMIM:600114 CCT3
UCSC:P49368 CCT3
Reference Transcript
RefSeq:NM_005998.4 CCT3
RefSeq:NM_001008800.2 CCT3
Other Identifiers
0003360575
11716382_a_at
11716383_x_at
11750144_x_at
11750432_a_at
11750433_x_at
16694529
200910_at
2438126
2438127
2438128
2438129
2438131
2438133
2438134
2438136
2438137
2438138
2438139
2438146
2438147
2438148
2438150
2438157
2438158
2438159
2438160
2438161
40774_at
7203
7920984
A_23_P160631
GE81585
GO:0000003
GO:0000166
GO:0002199
GO:0003674
GO:0003723
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005829
GO:0005832
GO:0005856
GO:0005874
GO:0005886
GO:0006259
GO:0006457
GO:0006810
GO:0007339
GO:0008150
GO:0009058
GO:0022607
GO:0032212
GO:0032991
GO:0034641
GO:0042592
GO:0043167
GO:0043226
GO:0044297
GO:0046931
GO:0050821
GO:0051082
GO:0051276
GO:0065003
GO:0070062
GO:1901998
GO:1904851
GO:1904871
GO:1904874
ILMN_1651828
ILMN_2334989
PH_hs_0000233
TC01003337.hg
TC01005857.hg
X74801_at
g5174726_3p_at
Participant Of
hasComponent
BBS/CCT complex [cytosol]
CCT/TRiC:ADP [cytosol]
CCT/TriC:ATP [cytosol]
CCT/TRiC:ATP:unfolded tubulin complex [cytosol]
Inferred To
Homologues of CCT3 [cytosol] (Gallus gallus)
cct-3 [cytosol] (Caenorhabditis elegans)
Ghost homologue of CCT3 [cytosol] (Sus scrofa)
cct3 [cytosol] (Danio rerio)
cct3 [cytosol] (Dictyostelium discoideum)
cct3 [cytosol] (Schizosaccharomyces pombe)
CCT3 [cytosol] (Canis familiaris)
CCT3 [cytosol] (Drosophila melanogaster)
CCT3 [cytosol] (Gallus gallus)
CCT3 [cytosol] (Plasmodium falciparum)
CCT3 [cytosol] (Saccharomyces cerevisiae)
nat10 [cytosol] (Xenopus tropicalis)
Cct3 [cytosol] (Mus musculus)
Cct3 [cytosol] (Rattus norvegicus)
Cross References
RefSeq
NP_001008800.1
,
NP_005989.3
OpenTargets
ENSG00000163468
HPA
ENSG00000163468-CCT3
GeneCards
P49368
Ensembl
ENSP00000357242
,
ENST00000295688
,
ENST00000368259
,
ENSG00000163468
,
ENSP00000295688
PRO
P49368
PDB
6QB8
,
6NR8
,
6NR9
,
6NRA
,
6NRC
,
6NRB
,
6NRD
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13371 PDCL
2
p-S18,S19,S20,S25-PDCL [cytosol]
(R-HSA-6814228)
PDCL [cytosol]
(R-HSA-6813727)
0.666
6
UniProt:Q13547 HDAC1
2
SUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
HDAC1 [nucleoplasm]
(R-HSA-205021)
0.643
4
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.643
3
UniProt:Q9BUR4 WRAP53
2
Unfolded WRAP53 [cytosol]
(R-HSA-6813830)
WRAP53 [nucleoplasm]
(R-HSA-418386)
0.597
5
UniProt:O75530 EED
1
EED [nucleoplasm]
(R-HSA-212278)
0.564
2
UniProt:O15160 POLR1C
2
POLR1C [nucleoplasm]
(R-HSA-63498)
POLR1C [cytosol]
(R-HSA-1964454)
0.556
3
UniProt:P04049 RAF1
54
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
RAF1 [cytosol]
(R-HSA-167205)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
p-S621-RAF1 G361A [cytosol]
(R-HSA-9656092)
p-S621-RAF1 G370R [cytosol]
(R-HSA-9656094)
p-S621-RAF1 D486G [cytosol]
(R-HSA-9656085)
p-S621-RAF1 T491R [cytosol]
(R-HSA-9656145)
p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]
(R-HSA-9656026)
p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]
(R-HSA-9656070)
p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]
(R-HSA-9656035)
p-S338,Y341,S494,S621-RAF1 T491I [cytosol]
(R-HSA-9656019)
p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]
(R-HSA-9656029)
p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]
(R-HSA-9656031)
p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]
(R-HSA-9656023)
p-S338,Y341,S494,S621 RAF1 T491R [cytosol]
(R-HSA-9656017)
p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]
(R-HSA-9656062)
p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]
(R-HSA-9656041)
p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]
(R-HSA-9656058)
p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]
(R-HSA-9656043)
p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]
(R-HSA-9656053)
p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]
(R-HSA-9656037)
p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]
(R-HSA-9656050)
p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]
(R-HSA-9656067)
p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]
(R-HSA-9656077)
p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]
(R-HSA-9656047)
p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]
(R-HSA-9656056)
p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]
(R-HSA-9656074)
p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]
(R-HSA-9656080)
p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]
(R-HSA-9656065)
hyperphosphorylated RAF1 [plasma membrane]
(R-HSA-5675193)
p-S621-RAF1 [plasma membrane]
(R-HSA-206222)
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5675420)
p-S259,S621-RAF1 [cytosol]
(R-HSA-109786)
p-S621-RAF1 [cytosol]
(R-HSA-206028)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5672665)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-HSA-5672664)
0.547
5
UniProt:Q16659 MAPK6
6
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
ub-MAPK6 [cytosol]
(R-HSA-5687000)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
MAPK6 [cytosol]
(R-HSA-5686979)
0.547
2
UniProt:Q13882 PTK6
5
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
PTK6 [cytosol]
(R-HSA-8848000)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
0.527
3
UniProt:Q00535 CDK5
4
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
CDK5 [nucleoplasm]
(R-HSA-8863586)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
0.527
2
UniProt:O43815 STRN
3
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
STRN [cytosol]
(R-HSA-9037081)
p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
0.527
2
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:Q8IWZ6 BBS7
1
BBS7 [cytosol]
(R-HSA-5617632)
0.462
2
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