Reactome | CCT3 [cytosol]

CCT3 [cytosol]

Stable Identifier

R-HSA-390463

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit gamma (TCP-1-gamma)

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - BBSome-mediated cargo-targeting to cilium (Homo sapiens)
      - Formation of the BBSome (Homo sapiens)
        
        BBS/CCT complex [cytosol] (Homo sapiens)
        
        CCT3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49368 CCT3

Gene Names

CCT3, CCTG, TRIC5

Chain

chain:1-545

Reference Genes

BioGPS Gene:7203 CCT3

COSMIC (genes):CCT3 CCT3

CTD Gene:7203 CCT3

dbSNP Gene:7203 CCT3

ENSEMBL:ENSG00000163468 CCT3

HGNC:1616 CCT3

KEGG Gene (Homo sapiens):7203 CCT3

Monarch:7203 CCT3

NCBI Gene:7203 CCT3

OMIM:600114 CCT3

UCSC:P49368 CCT3

Reference Transcript

Other Identifiers

0003360575

11716382_a_at

11716383_x_at

11750144_x_at

11750432_a_at

11750433_x_at

16694529

200910_at

2438126

2438127

2438128

2438129

2438131

2438133

2438134

2438136

2438137

2438138

2438139

2438146

2438147

2438148

2438150

2438157

2438158

2438159

2438160

2438161

40774_at

7203

7920984

A_23_P160631

GE81585

GO:0000003

GO:0000166

GO:0002199

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0005886

GO:0006259

GO:0006457

GO:0006810

GO:0007339

GO:0008150

GO:0009058

GO:0022607

GO:0032212

GO:0032991

GO:0034641

GO:0042592

GO:0043167

GO:0043226

GO:0044297

GO:0046931

GO:0050821

GO:0051082

GO:0051276

GO:0065003

GO:0070062

GO:1901998

GO:1904851

GO:1904871

GO:1904874

ILMN_1651828

ILMN_2334989

PH_hs_0000233

TC01003337.hg

TC01005857.hg

X74801_at

g5174726_3p_at

Participant Of

hasComponent

Inferred To

Homologues of CCT3 [cytosol] (Gallus gallus)

cct-3 [cytosol] (Caenorhabditis elegans)

Ghost homologue of CCT3 [cytosol] (Sus scrofa)

cct3 [cytosol] (Danio rerio)

cct3 [cytosol] (Dictyostelium discoideum)

cct3 [cytosol] (Schizosaccharomyces pombe)

cct3 [cytosol] (Xenopus tropicalis)

CCT3 [cytosol] (Bos taurus)

CCT3 [cytosol] (Canis familiaris)

CCT3 [cytosol] (Drosophila melanogaster)

CCT3 [cytosol] (Gallus gallus)

CCT3 [cytosol] (Plasmodium falciparum)

CCT3 [cytosol] (Saccharomyces cerevisiae)

Cct3 [cytosol] (Mus musculus)

Cct3 [cytosol] (Rattus norvegicus)

LOC101751456 [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_005989.3, NP_001008800.1

OpenTargets

ENSG00000163468

GeneCards

P49368

HPA

ENSG00000163468-CCT3

Ensembl

ENSP00000295688, ENSG00000163468, ENSP00000357242, ENST00000295688, ENST00000368259

PRO

P49368

PDB

6NRC, 6NRB, 6NRD, 6NR8, 6NR9, 6QB8, 6NRA

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13371 PDCL	2	p-S18,S19,S20,S25-PDCL [cytosol] (R-HSA-6814228) PDCL [cytosol] (R-HSA-6813727)	0.666	6
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.643	4
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.643	3
UniProt:Q9BUR4 WRAP53	2	Unfolded WRAP53 [cytosol] (R-HSA-6813830) WRAP53 [nucleoplasm] (R-HSA-418386)	0.597	5
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.564	2
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.556	3
UniProt:P04049 RAF1	54	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.547	5
UniProt:Q16659 MAPK6	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) ub-MAPK6 [cytosol] (R-HSA-5687000) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979)	0.547	2
UniProt:O43815 STRN	3	STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) STRN [cytosol] (R-HSA-9037081) p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908)	0.527	2
UniProt:Q00535 CDK5	4	CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	2
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) PTK6 [cytosol] (R-HSA-8848000) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103)	0.527	3
UniProt:Q8IWZ6 BBS7	1	BBS7 [cytosol] (R-HSA-5617632)	0.462	2

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