Striated Muscle Contraction

Stable Identifier
R-HSA-390522
Type
Pathway
Species
Homo sapiens
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Summation

Striated muscle contraction is a process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry, or in short, increased force being exerted on the tendons. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle composed of myofibrils, containing repeating units called sarcomeres, in which the contractile myofibrils are arranged in parallel to the axis of the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
Here striated muscle contraction is represented on the basis of calcium binding to the troponin complex, which exposes the active sites of actin. Once the active sites of actin are exposed, the myosin complex bound to ADP can bind actin and the myosin head can pivot, pulling the thin actin and thick myosin filaments past one another. Once the myosin head pivots, ADP is ejected, a fresh ATP can be bound and the energy from the hydrolysis of ATP to ADP is channeled into kinetic energy by resetting the myosin head. With repeated rounds of this cycle the sarcomere containing the thin and thick filaments effectively shortens, forming the basis of muscle contraction.

Literature References
PubMed ID Title Journal Year
15173218 The sliding filament model: 1972-2004

Cooke, R

J Gen Physiol 2004
13175187 Measurement of muscle striations in stretch and contraction

HUXLEY, AF, NIEDERGERKE, R

J Physiol 1954
13165697 Structural changes in muscle during contraction; interference microscopy of living muscle fibres

HUXLEY, AF, NIEDERGERKE, R

Nature 1954
  Regulatory Mechanisms of Striated Muscle Contraction

Ebashi, S, Ohtsuki, I

  2007
15173217 The early history of the biochemistry of muscle contraction

Szent-Györgyi, AG

J Gen Physiol 2004
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