Reactome | TNNC1 [cytosol]

TNNC1 [cytosol]

Stable Identifier

R-HSA-390533

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Troponin C, slow skeletal and cardiac muscles, TNNC1_HUMAN

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Striated Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin C:Calcium Complex [cytosol] (Homo sapiens)
        
        Troponin C [cytosol] (Homo sapiens)
        
        TNNC1 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin C:Calcium Complex [cytosol] (Homo sapiens)
        
        Troponin C [cytosol] (Homo sapiens)
        
        TNNC1 [cytosol] (Homo sapiens)
  - Calcium Binds Troponin-C (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin C:Calcium Complex [cytosol] (Homo sapiens)
        
        Troponin C [cytosol] (Homo sapiens)
        
        TNNC1 [cytosol] (Homo sapiens)
    - Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament [cytosol] (Homo sapiens)
        
        Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin C [cytosol] (Homo sapiens)
        
        TNNC1 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin C:Calcium Complex [cytosol] (Homo sapiens)
        
        Troponin C [cytosol] (Homo sapiens)
        
        TNNC1 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin C:Calcium Complex [cytosol] (Homo sapiens)
        
        Troponin C [cytosol] (Homo sapiens)
        
        TNNC1 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin C:Calcium Complex [cytosol] (Homo sapiens)
        
        Troponin C [cytosol] (Homo sapiens)
        
        TNNC1 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin C:Calcium Complex [cytosol] (Homo sapiens)
        
        Troponin C [cytosol] (Homo sapiens)
        
        TNNC1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P63316 TNNC1

Gene Names

TNNC1, TNNC

Chain

chain:1-161

Reference Genes

BioGPS Gene:7134 TNNC1

COSMIC (genes):TNNC1 TNNC1

CTD Gene:7134 TNNC1

dbSNP Gene:7134 TNNC1

ENSEMBL:ENSG00000114854 TNNC1

ENSEMBL_homo_sapiens_GENE:ENSG00000114854.8 TNNC1

HGNC:11943 TNNC1

KEGG Gene (Homo sapiens):7134 TNNC1

Monarch:7134 TNNC1

NCBI Gene:7134 TNNC1

OMIM:191040 TNNC1

Reference Transcript

RefSeq:NM_003280.2 TNNC1

Other Identifiers

11719268_at

16954817

209904_PM_at

209904_at

2676168

2676169

2676170

2676171

2676172

2676175

39085_at

7134

8087925

A_23_P166823

GE57960

GO:0002086

GO:0003009

GO:0003012

GO:0003013

GO:0003016

GO:0005509

GO:0005515

GO:0005829

GO:0005856

GO:0005861

GO:0006937

GO:0008092

GO:0010038

GO:0014883

GO:0031013

GO:0031014

GO:0032972

GO:0042803

GO:0043226

GO:0043292

GO:0043462

GO:0046872

GO:0048306

GO:0048856

GO:0050877

GO:0051015

GO:0055010

GO:0060048

GO:1990584

ILMN_1809842

M37984_rna1_at

TC03001455.hg

g2460248_3p_at

Participates

as a member of

Troponin C [cytosol] (Homo sapiens)

Inferred To

TNNC1 [cytosol] (Bos taurus)

TNNC1 [cytosol] (Gallus gallus)

TNNC1 [cytosol] (Mus musculus)

TNNC1 [cytosol] (Sus scrofa)

Tnnc1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_003271.1

OpenTargets

ENSG00000114854

GeneCards

P63316

HPA

ENSG00000114854-TNNC1

Ensembl

ENSP00000232975, ENST00000232975, ENSG00000114854

PRO

P63316

Pharos - Targets

P63316

Orphanet

17257

HMDB Protein

HMDBP08057

PDB

2MLF, 2JT8, 2MLE, 7UTI, 1OZS, 7UHA, 7SWI, 2KDH, 5VLN, 4Y99, 2KFX, 7SUP, 1IH0, 4GJE, 5WCL, 3SWB, 7SXC, 2N79, 1LXF, 7SC2, 6MV3, 2JXL, 1J1E, 2L1R, 5W88, 2JT3, 7SVC, 1AP4, 2MZP, 2KGB, 1MXL, 6KN8, 3SD6, 2L98, 2KRD, 7UTL, 2N7L, 4GJF, 7UH9, 1WRK, 2MKP, 7JGI, 7SWG, 3RV5, 2JT0, 1SPY, 6KN7, 2JTZ, 1WRL, 1J1D, 7SXD, 7SC3, 4GJG

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19429 TNNI3	2	p-S23,S24-TNNI3 [cytosol] (R-HSA-5617219) TNNI3 [cytosol] (R-HSA-390542)	0.536	4

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