Reactome | TPM3 [cytosol]

TPM3 [cytosol]

Stable Identifier

R-HSA-390543

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tropomyosin alpha-3 chain, TPM3_HUMAN

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
- Striated Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
  - Calcium Binds Troponin-C (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
    - Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOV GTPase cycle (Homo sapiens)
        
        RHOV binds effectors at the plasma membrane (Homo sapiens)
        
        RHOV effectors [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)
        
        RHOV:GTP:RHOV effectors [plasma membrane] (Homo sapiens)
        
        RHOV effectors [cytosol] (Homo sapiens)
        
        TPM3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P06753 TPM3

Gene Names

TPM3

Chain

initiator methionine:, chain:2-285, initiator methionine:, initiator methionine:

Reference Genes

BioGPS Gene:7170 TPM3

COSMIC (genes):TPM3 TPM3

CTD Gene:7170 TPM3

dbSNP Gene:7170 TPM3

ENSEMBL:ENSG00000143549 TPM3

HGNC:12012 TPM3

Monarch:7170 TPM3

NCBI Gene:7170 TPM3

OMIM:191030 TPM3

UCSC:P06753 TPM3

Reference Transcript

Other Identifiers

11715666_a_at

11715667_s_at

11721289_at

11731455_at

11746919_a_at

11749935_s_at

11750045_x_at

214365_PM_at

214365_at

222976_3p_s_at

222976_PM_s_at

222976_s_at

224164_PM_at

224164_at

238065_PM_at

238065_at

238079_PM_at

238079_at

2436522

2436523

2436525

2436527

2436528

2436529

2436530

2436531

2436532

2436533

2436534

2436535

2436536

2436537

2436538

2436539

2436540

2436541

2436542

2436543

2436544

2436545

2436546

2436547

2436548

2436550

2436552

2436553

2436554

2436557

2436558

2436559

2436560

2436562

2436563

2436564

2436565

2436566

2436567

2436569

2436570

2436571

2436572

2436574

2436575

3069273

32754_at

3588684

3660774

3815587

3834246

3834250

43197_at

51351_at

55837_at

57840_at

7170

73377_at

75021_at

7920472

8142468

89615_at

A_23_P310222

A_23_P346086

A_24_P393880

A_32_P119197

A_33_P3223980

A_33_P3223990

A_33_P3346193

GE753797

GE84825

GE85555

GO:0001725

GO:0003012

GO:0003674

GO:0003779

GO:0005515

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005862

GO:0005884

GO:0006936

GO:0007015

GO:0008092

GO:0015629

GO:0043226

GO:0051015

GO:0070062

HMNXSV003000428

HMNXSV003018117

HMNXSV003038944

Hs.146070.0.A1_3p_at

Hs.169514.0.A1_3p_at

Hs.85844.3.S1_3p_at

ILMN_1660775

ILMN_1686388

ILMN_1697567

ILMN_1747696

PH_hs_0029336

PH_hs_0040951

X04201_at

g12653954_3p_a_at

g12653954_3p_s_at

g12653954_3p_x_at

g9508584_3p_at

Participates

as a candidate of

RHOV effectors [cytosol] (Homo sapiens)

as a member of

Tropomyosin [cytosol] (Homo sapiens)

Other forms of this molecule

TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol]

TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol]

Inferred To

TPM1 [cytosol] (Saccharomyces cerevisiae)

Tpm3 [cytosol] (Mus musculus)

Tm1 [cytosol] (Drosophila melanogaster)

cdc8 [cytosol] (Schizosaccharomyces pombe)

TPM3 [cytosol] (Bos taurus)

TPM3 [cytosol] (Canis familiaris)

TPM3 [cytosol] (Gallus gallus)

lev-11 [cytosol] (Caenorhabditis elegans)

tpm3 [cytosol] (Danio rerio)

tpm3 [cytosol] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000143549

ENSEMBL

ENSP00000498577, ENST00000328159, ENST00000323144, ENSP00000341653, ENSP00000339035, ENST00000368531, ENST00000341485, ENST00000368533, ENSP00000307712, ENSP00000357518, ENSP00000357521, ENSP00000357517, ENSP00000357520, ENST00000651641, ENST00000302206, ENST00000330188

HPA

ENSG00000143549-TPM3

PRO

P06753

Pharos - Targets

P06753

Orphanet

TPM3

GlyGen

P06753

PDB

6OTN

HMDB Protein

HMDBP08072

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.849	10
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.735	7
UniProt:O14879 IFIT3	1	IFIT3 [cytosol] (R-HSA-947491)	0.696	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	14
UniProt:Q14164 IKBKE	5	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.589	2
UniProt:P21796 VDAC1	7	p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079)	0.564	4
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.556	3