Reactome | TPM1 [cytosol]

TPM1 [cytosol]

Stable Identifier

R-HSA-390547

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tropomyosin alpha-1 chain, TPM1_HUMAN

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
- Striated Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
  - Calcium Binds Troponin-C (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
    - Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P09493 TPM1

Gene Names

TPM1, C15orf13, TMSA

Chain

chain:1-284

Reference Genes

BioGPS Gene:7168 TPM1

COSMIC (genes):TPM1 TPM1

CTD Gene:7168 TPM1

dbSNP Gene:7168 TPM1

ENSEMBL:ENSG00000140416 TPM1

HGNC:12010 TPM1

KEGG:hsa:7168 TPM1

Monarch:7168 TPM1

NCBI Gene:7168 TPM1

OMIM:191010 TPM1

UCSC:P09493 TPM1

Reference Transcript

Participates

as a member of

Tropomyosin [cytosol] (Homo sapiens)

Inferred To

TPM1 [cytosol] (Bos taurus)

TPM1 [cytosol] (Canis familiaris)

TPM1 [cytosol] (Gallus gallus)

TPM1 [cytosol] (Sus scrofa)

tpm1 [cytosol] (Danio rerio)

Tm1 [cytosol] (Drosophila melanogaster)

Tpm1 [cytosol] (Mus musculus)

Tpm1 [cytosol] (Rattus norvegicus)

lev-11 [cytosol] (Caenorhabditis elegans)

Tm2 [cytosol] (Drosophila melanogaster)

Homologues of TPM1 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001018008.1, NP_001317280.1, NP_001394259.1, NP_001018006.1, NP_001018007.1, NP_001394260.1, NP_001317273.1, NP_001317275.1, NP_001018004.1, NP_000357.3, NP_001018005.1, NP_001288173.1, NP_001018020.1

OpenTargets

ENSG00000140416

ENSEMBL

ENSP00000288398, ENSP00000453955, ENST00000267996, ENSG00000140416, ENST00000403994, ENSP00000452879, ENSP00000351022, ENSP00000453941, ENST00000334895, ENST00000559556, ENST00000559397, ENSP00000267996, ENSP00000385107, ENST00000358278, ENSP00000334624, ENST00000561266, ENST00000288398

HPA

ENSG00000140416-TPM1

GeneCards

TPM1

PRO

P09493

Pharos - Targets

P09493

Orphanet

TPM1

GlyGen

P09493

HMDB Protein

HMDBP08070

PDB

7UTI, 3MUD, 8EFH, 5KHT, 8EFI, 6UT2, 8ENC, 8ZB7, 7UTL, 6X5Z

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.782	7
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.666	4
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.527	16

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