Reactome | ACTN2 [cytosol]

ACTN2 [cytosol]

Stable Identifier

R-HSA-390562

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Alpha-actinin-2, ACTN2_HUMAN

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Striated Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Z Disk Complex [cytosol] (Homo sapiens)
        
        Alpha-actinin [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Z Disk Complex [cytosol] (Homo sapiens)
        
        Alpha-actinin [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
  - Calcium Binds Troponin-C (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Z Disk Complex [cytosol] (Homo sapiens)
        
        Alpha-actinin [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
    - Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Z Disk Complex [cytosol] (Homo sapiens)
        
        Alpha-actinin [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Z Disk Complex [cytosol] (Homo sapiens)
        
        Alpha-actinin [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Z Disk Complex [cytosol] (Homo sapiens)
        
        Alpha-actinin [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Z Disk Complex [cytosol] (Homo sapiens)
        
        Alpha-actinin [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Z Disk Complex [cytosol] (Homo sapiens)
        
        Alpha-actinin [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Assembly and cell surface presentation of NMDA receptors (Homo sapiens)
        
        CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        GluN1 (GRIN1) binds to ACTN2 at postsynaptic density (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
      - Negative regulation of NMDA receptor-mediated neuronal transmission (Homo sapiens)
        
        CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
        
        Ras activation upon Ca2+ influx through NMDA receptor (Homo sapiens)
        
        Activation of RasGRF (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        NMDA-activated RASGRF1 activates RAS (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        Long-term potentiation (Homo sapiens)
        
        CaMKII binds activated NMDA receptor (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        CaMKII phosphorylates AMPA receptor (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:p-Y-GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
      - Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
        
        Ca2+ influx into the post-synaptic cell (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        ACTN2 homodimer [cytosol] (Homo sapiens)
        
        ACTN2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35609 ACTN2

Gene Names

ACTN2

Chain

chain:1-894

Reference Genes

BioGPS Gene:88 ACTN2

COSMIC (genes):ACTN2 ACTN2

CTD Gene:88 ACTN2

dbSNP Gene:88 ACTN2

ENSEMBL:ENSG00000077522 ACTN2

HGNC:164 ACTN2

KEGG:hsa:88 ACTN2

Monarch:88 ACTN2

NCBI Gene:88 ACTN2

OMIM:102573 ACTN2

UCSC:P35609 ACTN2

Reference Transcript

Other Identifiers

11734001_at

11734002_a_at

11734003_at

11749692_a_at

11751575_a_at

11758470_s_at

16679064

203861_PM_s_at

203861_s_at

203862_PM_s_at

203862_s_at

203863_PM_at

203863_at

203864_PM_s_at

203864_s_at

2386944

2386945

2386955

2386956

2386957

2386958

2386959

2386960

2386963

2386965

2386966

2386967

2386968

2386969

2386970

2386971

2386972

2386973

2386974

2386975

2386976

2386977

2386979

2386982

2386984

2386985

2386986

2386987

2386988

2386989

2386990

2386991

2386992

2386993

2386994

2386996

2386997

2386998

2386999

2387000

2387001

2387002

2387003

2387004

2387005

38448_at

61882_at

7910727

A_23_P115021

A_33_P3212167

GE61094

GE84365

GO:0003779

GO:0005178

GO:0005198

GO:0005509

GO:0005515

GO:0005546

GO:0005576

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005925

GO:0006355

GO:0007010

GO:0007155

GO:0008092

GO:0008289

GO:0008307

GO:0019904

GO:0030017

GO:0030018

GO:0030035

GO:0030036

GO:0030054

GO:0030175

GO:0030274

GO:0030374

GO:0030864

GO:0031093

GO:0031143

GO:0031432

GO:0034330

GO:0042391

GO:0042802

GO:0042981

GO:0042995

GO:0043197

GO:0043226

GO:0043267

GO:0043268

GO:0044325

GO:0045214

GO:0045893

GO:0046872

GO:0048041

GO:0048856

GO:0051015

GO:0051373

GO:0051695

GO:0055001

GO:0055013

GO:0060090

GO:0070062

GO:0070080

GO:0072659

GO:0086097

GO:0098839

GO:0098871

GO:0098973

GO:0098978

GO:0099092

GO:0140110

GO:1901017

GO:1901018

GO:2000009

GO:2001137

GO:2001259

HMNXSV003055491

Hs.83672.0.S1_3p_a_at

Hs.83672.0.S2_3p_a_at

Hs.83672.0.S4_3p_at

ILMN_1654422

M86406_at

PH_hs_0004772

TC01001955.hg

g4501892_3p_a_at

Participates

as a member of

as a component of

ACTN2 homodimer [cytosol] (Homo sapiens)

Other forms of this molecule

ACTN2 [platelet alpha granule lumen]

ACTN2 [extracellular region]

Inferred To

actn2b [cytosol] (Danio rerio)

atn-1 [cytosol] (Caenorhabditis elegans)

ACTN2 [cytosol] (Bos taurus)

ACTN2 [cytosol] (Canis familiaris)

ACTN2 [cytosol] (Drosophila melanogaster)

ACTN2 [cytosol] (Gallus gallus)

ACTN2 [cytosol] (Mus musculus)

ACTN2 [cytosol] (Sus scrofa)

Actn2 [cytosol] (Rattus norvegicus)

actn2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001265272.1, NP_001265273.1, NP_001094.1

OpenTargets

ENSG00000077522

ENSEMBL

ENSP00000443495, ENSP00000355537, ENST00000366578, ENST00000542672

HPA

ENSG00000077522-ACTN2

PRO

P35609

Pharos - Targets

P35609

Orphanet

ACTN2

GlyGen

P35609

PDB

1H8B, 1QUU, 4D1E, 7B55, 5A37, 5A38, 7B56, 7B57, 7A8U, 7A8T, 5A4B, 6SWT, 5A36, 1HCI, 6TS3

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.781	7
UniProt:P23497 SP100	3	polySUMO2-K297-SP100 [nucleoplasm] (R-HSA-3000454) monoSUMO1-K297-SP100 [nucleoplasm] (R-HSA-3000382) SP100 [nucleoplasm] (R-HSA-1031705)	0.666	6
UniProt:P03950 ANG	2	ANG [extracellular region] (R-HSA-5692435) ANG [cytosol] (R-HSA-9708345)	0.633	4
UniProt:P26842 CD27	1	CD27 [plasma membrane] (R-HSA-5666994)	0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.556	3
UniProt:P29373 CRABP2	2	SUMO-K102-CRABP2 [nucleoplasm] (R-HSA-5334813) SUMO-K102-CRABP2 [cytosol] (R-HSA-5334798)	0.556	3
UniProt:P78560 CRADD	1	CRADD [cytosol] (R-HSA-5657970)	0.556	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [cytosol] (R-HSA-446885) TOLLIP [specific granule lumen] (R-HSA-6799719) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [azurophil granule lumen] (R-HSA-6799709)	0.556	3
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.556	3
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.556	3
UniProt:P12814 ACTN1	3	ACTN1 [cytosol] (R-HSA-354096) ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722)	0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.547	2
UniProt:O75923 DYSF	1	DYSF [cytoplasmic vesicle membrane] (R-HSA-5263626)	0.454	2
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.454	2

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