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Release Of ADP From Myosin
Stable Identifier
R-HSA-390597
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Muscle contraction (Homo sapiens)
Striated Muscle Contraction (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The weak binding of the myosin head to the new site on the actin filament causes release of the inorganic phosphate produced by ATP hydrolysis, concomitantly with the tight binding of the head to actin. This release triggers the power stroke, a force-generating change in the shape during which the head regains its original conformation. In the course of the power stroke, the head loses its bound ADP, thereby returning to the start of a new cycle.
Literature References
PubMed ID
Title
Journal
Year
10747208
Regulation of contraction in striated muscle
Gordon, AM
,
Homsher, E
,
Regnier, M
Physiol Rev
2000
Regulatory Mechanisms of Striated Muscle Contraction
Ohtsuki, I
,
Ebashi, S
2007
Participants
Input
ADP:Calcium Bound Sarcomere Protein Complex [cytosol]
(Homo sapiens)
Output
x 2
ADP [cytosol]
Calcium Bound Sarcomere Protein Complex [cytosol]
(Homo sapiens)
Participates
as an event of
Striated Muscle Contraction (Homo sapiens)
Orthologous Events
Release Of ADP From Myosin (Bos taurus)
Release Of ADP From Myosin (Canis familiaris)
Release Of ADP From Myosin (Gallus gallus)
Release Of ADP From Myosin (Mus musculus)
Release Of ADP From Myosin (Rattus norvegicus)
Release Of ADP From Myosin (Sus scrofa)
Authored
Gillespie, ME (2003-07-01)
Reviewed
Rush, MG (2008-01-11)
Created
Gillespie, ME (2009-02-10)
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