ADRA1A,B,D bind ADR,NAd

Stable Identifier
R-HSA-390641
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Alpha-1 adrenoceptors bind catecholamines
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The alpha-1 adrenoceptors are involved in smooth muscle contraction. This is achieved by the receptor-ligand complex coupling with the G protein alpha-q/11 subtype, which results in increased intracellular calcium and thus muscle contraction. There are 3 subtypes of the alpha-1 adrenoceptor; 1a (Hirasawa A et al, 1993), 1b (Ramarao CS et al, 1992) and 1d (Esbenshade TA et al, 1995).

Literature References
PubMed ID Title Journal Year
7746284 Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells

Esbenshade, TA, Hirasawa, A, Tsujimoto, G, Tanaka, T, Yano, J, Minneman, KP, Murphy, TJ

Mol Pharmacol 1995
8396931 Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor

Hirasawa, A, Horie, K, Tanaka, T, Takagaki, K, Murai, M, Yano, J, Tsujimoto, G

Biochem Biophys Res Commun 1993
1328250 Genomic organization and expression of the human alpha 1B-adrenergic receptor

Ramarao, CS, Denker, JM, Perez, DM, Gaivin, RJ, Riek, RP, Graham, RM

J Biol Chem 1992
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