ADRA2A,B,C bind ADR,NAd

Stable Identifier
R-HSA-390663
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Alpha-2 adrenoceptors bind catecholamines
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Alpha-2 adrenoceptors couple with G protein alpha-i subtype which decreases adenylyl cyclase activity, thus reducing cAMP intracellular levels resulting in smooth muscle contraction. There are three alpha-2 subtypes in humans; 2A (Kobilka BK et al, 1987), 2B (Weinshank RL et al, 1990) and 2C (Hirasawa A et al, 1993).

Literature References
PubMed ID Title Journal Year
2823383 Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor

Kobilka, BK, Matsui, H, Kobilka, TS, Yang-Feng, TL, Francke, U, Caron, MG, Lefkowitz, RJ, Regan, JW

Science 1987
8396931 Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor

Hirasawa, A, Horie, K, Tanaka, T, Takagaki, K, Murai, M, Yano, J, Tsujimoto, G

Biochem Biophys Res Commun 1993
2172775 Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor

Weinshank, RL, Zgombick, JM, Macchi, M, Adham, N, Lichtblau, H, Branchek, TA, Hartig, PR

Mol Pharmacol 1990
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