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ADRA1A [plasma membrane]
Stable Identifier
R-HSA-390669
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Alpha-1A adrenoceptor, RecName: Full=Alpha-1A adrenergic receptor; AltName: Full=Alpha 1A-adrenoreceptor; AltName: Full=Alpha 1A-adrenoceptor; AltName: Full=Alpha-1C adrenergic receptor; AltName: Full=Alpha-adrenergic receptor 1c;
GN Name=ADRA1A; Synonyms=ADRA1C;
OS Homo sapiens, ADA1A_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
The Ligand:GPCR:G12/13 complex dissociates (Homo sapiens)
GPCRs that activate G12/13 [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Adrenoceptors (Homo sapiens)
ADRA1A,B,D bind ADR,NAd (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
α1-agonists:ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
α1-antagonists:ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
α1-agonists bind ADRA1A,B,D (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
α1-agonists:ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
α1-antagonists bind ADRA1A,B,D (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
α1-antagonists:ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A,B,D [plasma membrane] (Homo sapiens)
ADRA1A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35348 ADRA1A
Gene Names
ADRA1A, ADRA1C
Chain
chain:1-466
Reference Genes
BioGPS Gene:148 ADRA1A
COSMIC (genes):ADRA1A ADRA1A
CTD Gene:148 ADRA1A
dbSNP Gene:148 ADRA1A
ENSEMBL:ENSG00000120907 ADRA1A
ENSEMBL_homo_sapiens_GENE:ENSG00000120907.18 ADRA1A
HGNC:277 ADRA1A
KEGG Gene (Homo sapiens):148 ADRA1A
Monarch:148 ADRA1A
NCBI Gene:148 ADRA1A
OMIM:104221 ADRA1A
UCSC:P35348 ADRA1A
Reference Transcript
RefSeq:NM_001322502.1 ADRA1A
RefSeq:NM_000680.3 ADRA1A
RefSeq:XM_011544411.2 ADRA1A
RefSeq:NM_001322504.1 ADRA1A
RefSeq:NM_033303.4 ADRA1A
RefSeq:NM_001322503.1 ADRA1A
RefSeq:XM_006716293.3 ADRA1A
RefSeq:NM_033302.3 ADRA1A
RefSeq:NM_033304.3 ADRA1A
Other Identifiers
11738641_a_at
11738830_x_at
11738842_a_at
11762652_at
148
211489_PM_at
211489_at
211490_PM_at
211490_at
211491_PM_at
211491_at
211492_PM_s_at
211492_s_at
243146_PM_at
243146_at
3128823
3128824
3128827
3128828
3128838
3128839
3128841
3128842
3128843
3128844
3128845
3128846
3128851
3128852
3128870
3128871
3128874
3128875
3128876
3128881
3128882
36715_at
36716_at
A_23_P8938
A_33_P3332248
A_33_P3377194
D32202_at
GE57176
GO:0000165
GO:0001985
GO:0001994
GO:0001996
GO:0001997
GO:0003012
GO:0003013
GO:0004930
GO:0004935
GO:0004937
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0005901
GO:0006914
GO:0006915
GO:0006937
GO:0006939
GO:0007165
GO:0007186
GO:0007200
GO:0007202
GO:0007204
GO:0007267
GO:0007512
GO:0008217
GO:0008285
GO:0009410
GO:0009725
GO:0010507
GO:0010613
GO:0012501
GO:0016020
GO:0019229
GO:0023052
GO:0030154
GO:0031965
GO:0032230
GO:0035265
GO:0035556
GO:0043226
GO:0043231
GO:0043410
GO:0045760
GO:0045907
GO:0045987
GO:0046982
GO:0048856
GO:0050877
GO:0055085
GO:0055117
GO:0060089
GO:0060402
GO:0060452
GO:0061049
GO:0070374
GO:0071875
GO:0071880
GO:0090037
GO:0097195
GO:0150099
HMNXSV003007511
HMNXSV003016396
HMNXSV003019189
HMNXSV003049530
Hs.289389.0.A1_3p_at
ILMN_1653821
ILMN_1669227
ILMN_1709167
ILMN_1780551
ILMN_1813598
PH_hs_0003537
TC08002262.hg
g2978555_3p_at
g409028_3p_a_at
g409028_3p_x_at
g927208_3p_at
g927210_3p_at
p23932
Participates
as a member of
ADRA1A,B,D [plasma membrane] (Homo sapiens)
Inferred To
ADRA1A [plasma membrane]
(Bos taurus)
ADRA1A [plasma membrane]
(Canis familiaris)
ADRA1A [plasma membrane]
(Gallus gallus)
ADRA1A [plasma membrane]
(Sus scrofa)
Homologues of ADRA1A [plasma membrane]
(Drosophila melanogaster)
ser-5 [plasma membrane]
(Caenorhabditis elegans)
Adra1a [plasma membrane]
(Mus musculus)
Adra1a [plasma membrane]
(Rattus norvegicus)
TyrRII [plasma membrane]
(Drosophila melanogaster)
adra1a [plasma membrane]
(Xenopus tropicalis)
DopEcR [plasma membrane]
(Drosophila melanogaster)
TyrR [plasma membrane]
(Drosophila melanogaster)
Dmel\CG12290 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001309432.1
,
NP_150646.3
,
XP_006716356.1
,
XP_011542713.1
,
NP_001309433.1
,
NP_150645.2
,
NP_000671.2
,
NP_001309431.1
,
NP_150647.2
ZINC - World Drugs
ADA1A_HUMAN
Guide to Pharmacology - Targets
22
OpenTargets
ENSG00000120907
ZINC - FDA approved
ADA1A_HUMAN
ZINC - Substances
ADA1A_HUMAN
ZINC target
P35348
ZINC - Biogenic
ADA1A_HUMAN
PRO
P35348
PDB
8THL
,
8HN1
,
7YM8
,
7YMJ
,
8THK
,
7YMH
ZINC - Investigational
ADA1A_HUMAN
ZINC - Metabolites
ADA1A_HUMAN
HPA
ENSG00000120907-ADRA1A
GeneCards
P35348
Ensembl
ENSP00000369947
,
ENST00000354550
,
ENSP00000430414
,
ENSP00000276393
,
ENSP00000346557
,
ENSP00000431073
,
ENSP00000369960
,
ENST00000380572
,
ENSP00000369956
,
ENST00000380582
,
ENST00000380573
,
ENSP00000369946
,
ENST00000521711
,
ENST00000380586
,
ENST00000519096
,
ENST00000276393
,
ENSG00000120907
Pharos - Targets
P35348
ZINC - Predictions - Purchasable
ADA1A_HUMAN
HMDB Protein
HMDBP07433
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61073 CXCR4
1
CXCR4 [plasma membrane]
(R-HSA-2980772)
0.606
10
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