Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
CHRM4 [plasma membrane]
Stable Identifier
R-HSA-390693
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
M4, RecName: Full=Muscarinic acetylcholine receptor M4;
GN Name=CHRM4;
OS Homo sapiens, ACM4_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
CHRM4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
CHRM4 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
CHRM4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
CHRM4 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
CHRM4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
CHRM4 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Muscarinic acetylcholine receptors (Homo sapiens)
CHRM2,4 bind acetylcholine (Homo sapiens)
CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
CHRM4 [plasma membrane] (Homo sapiens)
CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
CHRM4 [plasma membrane] (Homo sapiens)
CHRM4 binds CHRM4 antagonists (Homo sapiens)
CHRM4 [plasma membrane] (Homo sapiens)
CHRM4:CHRM4 antagonists [plasma membrane] (Homo sapiens)
CHRM4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08173 CHRM4
Gene Names
CHRM4
Chain
chain:1-479
Reference Genes
BioGPS Gene:1132 CHRM4
COSMIC (genes):CHRM4 CHRM4
CTD Gene:1132 CHRM4
dbSNP Gene:1132 CHRM4
ENSEMBL:ENSG00000180720 CHRM4
ENSEMBL_homo_sapiens_GENE:ENSG00000180720.8 CHRM4
HGNC:1953 CHRM4
KEGG Gene (Homo sapiens):1132 CHRM4
Monarch:1132 CHRM4
NCBI Gene:1132 CHRM4
OMIM:118495 CHRM4
UCSC:P08173 CHRM4
Reference Transcript
RefSeq:NM_000741.3 CHRM4
Other Identifiers
1132
11746745_a_at
16737715
221357_PM_at
221357_at
242203_PM_at
242203_at
3371538
3371539
3371540
3371541
3371542
3371543
3371552
61404_at
7947649
ADDON002751.hg
A_23_P104845
A_33_P3367850
GE568378
GO:0004930
GO:0004993
GO:0005886
GO:0007165
GO:0007166
GO:0007186
GO:0007187
GO:0007197
GO:0007213
GO:0007268
GO:0016020
GO:0016907
GO:0023052
GO:0030425
GO:0040012
GO:0045202
GO:0045211
GO:0060089
GO:0095500
GO:0098664
HMNXSV003014354
Hs.9801.0.A1_3p_at
ILMN_1660882
M16405_at
PH_hs_0032309
TC11001719.hg
g4502820_3p_at
Participates
as a component of
CHRM4:CHRM4 antagonists [plasma membrane] (Homo sapiens)
as an input of
CHRM4 binds CHRM4 antagonists (Homo sapiens)
as a member of
CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
Inferred To
Chrm4 [plasma membrane]
(Mus musculus)
Chrm4 [plasma membrane]
(Rattus norvegicus)
CHRM4 [plasma membrane]
(Canis familiaris)
CHRM4 [plasma membrane]
(Gallus gallus)
CHRM4 [plasma membrane]
(Sus scrofa)
gar-3 [plasma membrane]
(Caenorhabditis elegans)
chrm4 [plasma membrane]
(Xenopus tropicalis)
mAChR-A [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000732.2
ZINC - World Drugs
ACM4_HUMAN
Guide to Pharmacology - Targets
16
OpenTargets
ENSG00000180720
ZINC - FDA approved
ACM4_HUMAN
ZINC - Substances
ACM4_HUMAN
ZINC - Biogenic
ACM4_HUMAN
ZINC target
P08173
PRO
P08173
PDB
7V6A
,
7LD3
,
7V69
,
7TRK
,
7TRS
,
7V68
,
8E9X
,
7TRP
,
7LD4
,
6KP6
,
6D9H
,
8FX5
,
7TRQ
,
5DSG
ZINC - Investigational
ACM4_HUMAN
ZINC - Metabolites
ACM4_HUMAN
GeneCards
P08173
HPA
ENSG00000180720-CHRM4
Ensembl
ENST00000433765
,
ENST00000682254
,
ENSP00000507561
,
ENSG00000180720
,
ENSP00000409378
Pharos - Targets
P08173
ZINC - Predictions - Purchasable
ACM4_HUMAN
HMDB Protein
HMDBP10811
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62873-1 GNB1
0.488
2
UniProt:P59768 GNG2
1
GNG2 [plasma membrane]
(R-HSA-164380)
0.488
2
UniProt:P04899-1 GNAI2
0.488
2
UniProt:P28335 HTR2C
1
HTR2C [plasma membrane]
(R-HSA-390965)
0.471
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text