Reactome | DRD3 [plasma membrane]

DRD3 [plasma membrane]

Stable Identifier

R-HSA-390834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Dopamine receptor 3, DRD3_HUMAN, RecName: Full=D

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        DRD3,4:DA [plasma membrane] (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        DRD3,4:DA [plasma membrane] (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD3 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        DRD3,4:DA [plasma membrane] (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        DRD3,4:DA [plasma membrane] (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD3 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        DRD3,4:DA [plasma membrane] (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        DRD3,4:DA [plasma membrane] (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD3 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Dopamine receptors (Homo sapiens)
        
        D2D3,4 bind to DA (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD3 [plasma membrane] (Homo sapiens)
        
        DRD3,4:DA [plasma membrane] (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35462 DRD3

Gene Names

DRD3

Chain

chain:1-400

Reference Genes

BioGPS Gene:1814 DRD3

COSMIC (genes):DRD3 DRD3

CTD Gene:1814 DRD3

dbSNP Gene:1814 DRD3

ENSEMBL:ENSG00000151577 DRD3

ENSEMBL_homo_sapiens_GENE:ENSG00000151577.14 DRD3

HGNC:3024 DRD3

KEGG Gene (Homo sapiens):1814 DRD3

Monarch:1814 DRD3

NCBI Gene:1814 DRD3

OMIM:126451 DRD3

Reference Transcript

Other Identifiers

11744701_a_at

16957612

1814

211625_PM_s_at

211625_s_at

214559_PM_at

214559_at

2689379

2689380

2689381

2689382

2689383

2689384

2689385

2689386

2689390

2689391

2689392

2689393

2689398

2689401

2689402

2689403

2689408

2689410

2689411

2689412

2689413

32491_at

32492_g_at

8089679

GE59032

GO:0000278

GO:0000910

GO:0001591

GO:0001963

GO:0002031

GO:0003013

GO:0004930

GO:0004952

GO:0005515

GO:0005886

GO:0006874

GO:0007165

GO:0007186

GO:0007191

GO:0007195

GO:0007200

GO:0007611

GO:0007612

GO:0007626

GO:0008542

GO:0009410

GO:0014059

GO:0016020

GO:0016192

GO:0023052

GO:0030154

GO:0032467

GO:0032922

GO:0034776

GO:0035176

GO:0042220

GO:0042417

GO:0043266

GO:0043278

GO:0045202

GO:0045776

GO:0045840

GO:0046717

GO:0048148

GO:0048715

GO:0048856

GO:0050482

GO:0050709

GO:0050877

GO:0050883

GO:0051481

GO:0051584

GO:0051898

GO:0051967

GO:0055065

GO:0060089

GO:0060134

GO:0060158

GO:0060161

GO:0071880

GO:0140014

HMNXSV003018157

ILMN_2268990

ILMN_2361810

L20469_s_at

PH_hs_0006753

TC03001667.hg

TC03003037.hg

U32499_s_at

g306688_3p_s_at

p33880

Participates

as a member of

DRD3,4 [plasma membrane] (Homo sapiens)

Inferred To

fd16a06 [plasma membrane] (Danio rerio)

DRD3 [plasma membrane] (Bos taurus)

DRD3 [plasma membrane] (Canis familiaris)

DRD3 [plasma membrane] (Gallus gallus)

DRD3 [plasma membrane] (Sus scrofa)

dop-3 [plasma membrane] (Caenorhabditis elegans)

Dop2R [plasma membrane] (Drosophila melanogaster)

Drd3 [plasma membrane] (Mus musculus)

Drd3 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

XP_016861318.1, NP_001269492.1, NP_001277738.1, NP_387512.3, NP_000787.2

ZINC - World Drugs

DRD3_HUMAN

Guide to Pharmacology - Targets

216

OpenTargets

ENSG00000151577

ZINC - FDA approved

DRD3_HUMAN

ZINC - Substances

DRD3_HUMAN

ZINC target

P35462

ZINC - Biogenic

DRD3_HUMAN

PRO

P35462

PDB

3PBL, 7CMV, 7CMU, 8IRT

ZINC - Investigational

DRD3_HUMAN

ZINC - Metabolites

DRD3_HUMAN

HPA

ENSG00000151577-DRD3

GeneCards

P35462

Ensembl

ENST00000295881, ENST00000460779, ENST00000467632, ENST00000383673, ENSP00000420662, ENSP00000373169, ENSG00000151577, ENSP00000419402, ENSP00000295881

Pharos - Targets

P35462

Orphanet

15890

ZINC - Predictions - Purchasable

DRD3_HUMAN

HMDB Protein

HMDBP10806