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HRH4 binds Hist
Stable Identifier
R-HSA-390886
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Histamine receptors (Homo sapiens)
HRH4 binds Hist (Homo sapiens)
General
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Histamine H4 receptor (HRH4) (Nakamura et al. 2000) is highly expressed in bone marrow and white blood cells. It is also found in other tissues such as colon, liver, lungs and thymus. HRH4 mediates mast cell chemotaxis. Both the H3 and H4 receptors mediate their actions by coupling with the G protein alpha-i subtype, decreasing intracellular cAMP.
Literature References
PubMed ID
Title
Journal
Year
11118334
Molecular cloning and characterization of a new human histamine receptor, HH4R
Tanaka, K
,
Ohta, M
,
Nakamura, T
,
Hidaka, Y
,
Itadani, H
Biochem Biophys Res Commun
2000
Participants
Input
Hist [extracellular region]
HRH4 [plasma membrane]
(Homo sapiens)
Output
HRH4:Hist [plasma membrane]
(Homo sapiens)
Participates
as an event of
Histamine receptors (Homo sapiens)
Orthologous Events
HRH4 binds Hist (Bos taurus)
HRH4 binds Hist (Caenorhabditis elegans)
HRH4 binds Hist (Canis familiaris)
HRH4 binds Hist (Drosophila melanogaster)
HRH4 binds Hist (Gallus gallus)
HRH4 binds Hist (Mus musculus)
HRH4 binds Hist (Rattus norvegicus)
Authored
Jassal, B (2009-02-11)
Reviewed
D'Eustachio, P (2009-03-02)
Created
Jassal, B (2009-02-11)
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