5-HT4, 6 and 7 receptors can bind serotonin

Stable Identifier
R-HSA-390931
Type
Reaction [binding]
Species
Homo sapiens
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The 5-HT4 receptor (Van den Wyngaert I et al, 1997) is located in the alimentary tract, bladder, heart and adrenal gland as well as the central nervous system (CNS). It modulates the release of various neurotransmitters. Multiple transcripts encode proteins with distinct C-terminal sequences, but the full-length nature of some transcript variants has not been determined (Blondel O et al, 1998). The 5-HT6 receptor (Kohen R et al, 1996) is primarily expressed in the brain and is involved in glutamatergic and cholinergic neuronal activity. The 5-HT7 receptor (Stam NJ et al, 1997) plays a role in vasculature smooth muscle relaxation and in the GI tract. It is involved in thermoregulation, circadian rhythm, learning and memory, and sleep.
All these receptor types mediate their actions by coupling to the G protein alpha-s subtype, which increases cellular cAMP levels (Baker LP et al, 1998; Zhang JY et al, 2003).



Literature References
PubMed ID Title Journal Year
12860470 Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein

Zhang, JY, Nawoschik, S, Kowal, D, Smith, D, Spangler, T, Ochalski, R, Schechter, L, Dunlop, J

Eur J Pharmacol 2003
9651336 Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor

Baker, LP, Nielsen, MD, Impey, S, Metcalf, MA, Poser, SW, Chan, G, Obrietan, K, Hamblin, MW, Storm, DR

J Biol Chem 1998
9349523 Cloning and expression of a human serotonin 5-HT4 receptor cDNA

Van den Wyngaert, I, Gommeren, W, Verhasselt, P, Jurzak, M, Leysen, J, Luyten, W, Bender, E

J Neurochem 1997
9603189 Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus

Blondel, O, Gastineau, M, Dahmoune, Y, Langlois, M, Fischmeister, R

J Neurochem 1998
9303561 Human serotonin 5-HT7 receptor: cloning and pharmacological characterisation of two receptor variants

Stam, NJ, Roesink, C, Dijcks, F, Garritsen, A, van Herpen, A, Olijve, W

FEBS Lett 1997
8522988 Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor

Kohen, R, Metcalf, MA, Khan, N, Druck, T, Huebner, K, Lachowicz, JE, Meltzer, HY, Sibley, DR, Roth, BL, Hamblin, MW

J Neurochem 1996
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