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HTR1A [plasma membrane]
Stable Identifier
R-HSA-390971
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
5-HT1A receptor, RecName: Full=5-hydroxytryptamine receptor 1A; Short=5-HT-1A; Short=5-HT1A; AltName: Full=Serotonin receptor 1A; AltName: Full=G-21;
GN Name=HTR1A; Synonyms=ADRB2RL1, ADRBRL1;
OS Homo sapiens, 5HT1A_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P11362
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Serotonin receptors (Homo sapiens)
HTR1A binds 5HT (Homo sapiens)
HTR1A [plasma membrane] (Homo sapiens)
HTR1A binds HTR1A agonists (Homo sapiens)
HTR1A [plasma membrane] (Homo sapiens)
HTR1A binds HTR1A antagonists (Homo sapiens)
HTR1A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08908 HTR1A
Gene Names
HTR1A, ADRB2RL1, ADRBRL1
Chain
chain:1-422
Reference Genes
BioGPS Gene:3350 HTR1A
COSMIC (genes):HTR1A HTR1A
CTD Gene:3350 HTR1A
dbSNP Gene:3350 HTR1A
ENSEMBL:ENSG00000178394 HTR1A
ENSEMBL_homo_sapiens_GENE:ENSG00000178394.5 HTR1A
HGNC:5286 HTR1A
KEGG Gene (Homo sapiens):3350 HTR1A
Monarch:3350 HTR1A
NCBI Gene:3350 HTR1A
OMIM:109760 HTR1A
Reference Transcript
RefSeq:NM_000524.3 HTR1A
Other Identifiers
11741081_a_at
11741082_at
16996667
16996670
221351_PM_at
221351_at
236714_PM_at
236714_at
2859388
2859389
2859390
2859391
2859392
2859393
2859394
2859395
2859396
2859397
2859398
3350
47305_at
8112333
ADDON002886.hg
A_24_P97687
GE547469
GE554019
GO:0001662
GO:0003013
GO:0004930
GO:0004993
GO:0005515
GO:0005886
GO:0007165
GO:0007186
GO:0007187
GO:0007198
GO:0007210
GO:0007214
GO:0007268
GO:0007610
GO:0008284
GO:0014062
GO:0016020
GO:0019229
GO:0023052
GO:0030425
GO:0030594
GO:0035640
GO:0042053
GO:0042428
GO:0042995
GO:0045202
GO:0046883
GO:0050795
GO:0051378
GO:0060089
GO:0090722
GO:0098664
HMNXSV003031338
HMNXSV003052920
Hs.56400.0.A1_3p_at
Hs.56400.0.A1_3p_x_at
ILMN_1813690
M83181_at
TC05001404.hg
g4504530_3p_at
p13190
Participates
as a component of
HTR1A:HTR1A Antagonist drugs [plasma membrane] (Homo sapiens)
HTR1A:HTR1A agonists [plasma membrane] (Homo sapiens)
HTR1A:5HT [plasma membrane] (Homo sapiens)
as an input of
HTR1A binds HTR1A antagonists (Homo sapiens)
HTR1A binds HTR1A agonists (Homo sapiens)
HTR1A binds 5HT (Homo sapiens)
Inferred To
5-HT1B [plasma membrane]
(Drosophila melanogaster)
HTR1A [plasma membrane]
(Bos taurus)
HTR1A [plasma membrane]
(Canis familiaris)
HTR1A [plasma membrane]
(Danio rerio)
HTR1A [plasma membrane]
(Gallus gallus)
HTR1A [plasma membrane]
(Mus musculus)
HTR1A [plasma membrane]
(Rattus norvegicus)
5-HT1A [plasma membrane]
(Drosophila melanogaster)
Homologues of HTR1A [plasma membrane]
(Drosophila melanogaster)
ser-4 [plasma membrane]
(Caenorhabditis elegans)
LOC100489755 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000515.2
ZINC - World Drugs
5HT1A_HUMAN
Guide to Pharmacology - Targets
1
OpenTargets
ENSG00000178394
ZINC - FDA approved
5HT1A_HUMAN
ZINC - Substances
5HT1A_HUMAN
ZINC target
P08908
ZINC - Biogenic
5HT1A_HUMAN
PRO
P08908
PDB
7E2Y
,
7E2Z
,
7E2X
ZINC - Investigational
5HT1A_HUMAN
ZINC - Metabolites
5HT1A_HUMAN
HPA
ENSG00000178394-HTR1A
GeneCards
P08908
Ensembl
ENSP00000316244
,
ENST00000323865
,
ENSG00000178394
Pharos - Targets
P08908
ZINC - Predictions - Purchasable
5HT1A_HUMAN
Orphanet
26389
HMDB Protein
HMDBP02566
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11362 FGFR1
9
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
FGFR1 [plasma membrane]
(R-HSA-9756433)
0.62
9
UniProt:P47211 GALR1
1
GALR1 [plasma membrane]
(R-HSA-388967)
0.585
4
UniProt:O43194 GPR39
1
GPR39 [plasma membrane]
(R-HSA-443953)
0.571
4
UniProt:P08908 HTR1A
1
HTR1A [plasma membrane]
(R-HSA-390971)
0.509
4
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