p-4Y-SIRPA:CD47 binds GRB2-1

Stable Identifier
R-HSA-391153
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Synonyms
Recruitment of Grb2 to pSIRP alpha
ReviewStatus
5/5
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p-4Y-SIRPA:CD47 binds GRB2-1
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GRB2 binds to phosphorylated tyrosine residues in SIRP alpha (SIRPA) in vitro; this interaction has negative regulatory effects on cellular responses induced by growth factors, oncogenes or insulin.
Literature References
PubMed ID Title Journal Year
9062191 A family of proteins that inhibit signalling through tyrosine kinase receptors

Chen, Z, Ullrich, A, Wang, H, Kharitonenkov, A, Schilling, J, Sures, I

Nature 1997
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Orthologous Events
p-4Y-SIRPA:CD47 binds GRB2-1 (Bos taurus)
p-4Y-SIRPA:CD47 binds GRB2-1 (Canis familiaris)
p-4Y-SIRPA:CD47 binds GRB2-1 (Gallus gallus)
p-4Y-SIRPA:CD47 binds GRB2-1 (Mus musculus)
p-4Y-SIRPA:CD47 binds GRB2-1 (Rattus norvegicus)
p-4Y-SIRPA:CD47 binds GRB2-1 (Sus scrofa)
Authored
Garapati, P V  (2009-02-12)
Reviewed
Barclay, AN  (2010-05-20)
Created
Garapati, P V  (2009-02-12)
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