Reactome | TAAR2 [plasma membrane]

TAAR2 [plasma membrane]

Stable Identifier

R-HSA-391208

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

RecName: Full=Trace amine-associated receptor 2; AltName: Full=G-protein coupled receptor 58; GN Name=TAAR2; Synonyms=GPR58; OS Homo sapiens, TAAR2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR2 [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR2 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR2 [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR2 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Trace amine-associated receptors can bind trace amines (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR2 [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P1P5 TAAR2

Gene Names

TAAR2, GPR58

Chain

chain:1-351

Reference Genes

BioGPS Gene:9287 TAAR2

COSMIC (genes):TAAR2 TAAR2

CTD Gene:9287 TAAR2

dbSNP Gene:9287 TAAR2

ENSEMBL:ENSG00000146378 TAAR2

ENSEMBL_homo_sapiens_GENE:ENSG00000146378.6 TAAR2

HGNC:4514 TAAR2

Monarch:9287 TAAR2

NCBI Gene:9287 TAAR2

OMIM:604849 TAAR2

UCSC:Q9P1P5 TAAR2

Reference Transcript

Other Identifiers

11734584_at

17023699

221394_PM_at

221394_at

2974564

2974567

2974568

2974569

2974575

8129610

9287

ADDON002672.hg

A_23_P70733

GE80685

GO:0001594

GO:0004930

GO:0005886

GO:0007165

GO:0007186

GO:0016020

GO:0023052

GO:0060089

HMNXSV003007292

ILMN_2412141

PH_hs_0014062

TC06002117.hg

TC06003851.hg

TC06003853.hg

g7657141_3p_at

Participates

as a candidate of

Trace amine-associated receptor [plasma membrane] (Homo sapiens)

Inferred To

si:dkey-7c18.21 [plasma membrane] (Danio rerio)

taar69 [plasma membrane] (Danio rerio)

si:ch211-119b12.1 [plasma membrane] (Danio rerio)

Taar2 [plasma membrane] (Mus musculus)

Taar2 [plasma membrane] (Rattus norvegicus)

TAAR2 [plasma membrane] (Bos taurus)

npr-42 [plasma membrane] (Caenorhabditis elegans)

si:dkey-7c18.1 [plasma membrane] (Danio rerio)

si:dkey-7c18.20 [plasma membrane] (Danio rerio)

si:ch211-119b12.3 [plasma membrane] (Danio rerio)

Homologues of TAAR2 [plasma membrane] (Danio rerio)

si:dkey-7c18.19 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_055441.2, NP_001028252.1

Guide to Pharmacology - Targets

167

OpenTargets

ENSG00000146378

HPA

ENSG00000146378-TAAR2

GeneCards

Q9P1P5

Ensembl

ENSP00000356908, ENST00000367931, ENSP00000275191, ENSG00000146378, ENST00000275191

PRO

Q9P1P5

Pharos - Targets

Q9P1P5