Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
TSHR [plasma membrane]
Stable Identifier
R-HSA-391371
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
TSH receptor, RecName: Full=Thyrotropin receptor; AltName: Full=Thyroid-stimulating hormone receptor; Short=TSH-R; Flags: Precursor;
GN Name=TSHR; Synonyms=LGR3;
OS Homo sapiens, TSHR_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
TSHR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
TSHR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
TSHR [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
TSHR [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Hormone ligand-binding receptors (Homo sapiens)
Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Homo sapiens)
TSHR [plasma membrane] (Homo sapiens)
TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
TSHR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16473 TSHR
Gene Names
TSHR, LGR3
Chain
signal peptide:1-20, chain:21-764
Reference Genes
BioGPS Gene:7253 TSHR
COSMIC (genes):TSHR TSHR
CTD Gene:7253 TSHR
dbSNP Gene:7253 TSHR
ENSEMBL:ENSG00000165409 TSHR
HGNC:12373 TSHR
KEGG Gene (Homo sapiens):7253 TSHR
Monarch:7253 TSHR
NCBI Gene:7253 TSHR
UCSC:P16473 TSHR
Reference Transcript
RefSeq:NM_001142626.2 TSHR
RefSeq:XM_005268039.1 TSHR
RefSeq:NM_000369.2 TSHR
RefSeq:NM_001018036.2 TSHR
RefSeq:XM_006720245.1 TSHR
Other Identifiers
11730683_a_at
16787068
215442_s_at
215443_at
34514_at
34515_g_at
3546216
3546217
3546218
3546257
3546258
3546263
3546264
3546265
3546266
3546268
3546269
3546270
3546271
3546272
3546273
473
7253
7976037
A0A0A0MTJ0
A0A2R8Y709
A_14_P130131
CAB000473
CCDS32131
CCDS55935
ENSG00000165409
ENSP00000340113
ENSP00000450549
ENST00000342443
ENST00000342443.10
ENST00000554435
ENST00000554435.1
EntrezGene:7253
EntrezGene:TSHR
G3V381
GO:0003674
GO:0004930
GO:0004996
GO:0005515
GO:0005575
GO:0005623
GO:0005886
GO:0005887
GO:0007165
GO:0007166
GO:0007186
GO:0007187
GO:0007189
GO:0007190
GO:0007267
GO:0008150
GO:0008283
GO:0008284
GO:0008528
GO:0009755
GO:0009986
GO:0016020
GO:0016021
GO:0016323
GO:0016500
GO:0032991
GO:0038023
GO:0038194
GO:0042592
GO:0043235
GO:0044877
GO:0120162
GO:1904588
GO:1905229
HGNC:12373
Hs.123078.1.S1_3p_at
ILMN_1660639
ILMN_2314121
IPR002274
IPR026906
IPR032675
LRG_523
LRG_523t1
MIM:275200
MIM:603372
MIM:603373
MIM:609152
NM_001018036
NM_001142626
NP_001018046
NP_001136098
PF13306
PR01145
Q0VAP8
TSHR
TSHR-202
TSHR-206
UPI000006E162
UPI00018830B9
XM_005268039
XM_006720245
XP_005268096
XP_006720308
Participant Of
input
Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin
hasMember
GPCRs that activate Gs [plasma membrane]
hasComponent
TSHR:Thyrotropin [plasma membrane]
Inferred To
TSHR [plasma membrane] (Bos taurus)
TSHR [plasma membrane] (Caenorhabditis elegans)
TSHR [plasma membrane] (Danio rerio)
TSHR [plasma membrane] (Drosophila melanogaster)
TSHR [plasma membrane] (Gallus gallus)
TSHR [plasma membrane] (Mus musculus)
TSHR [plasma membrane] (Rattus norvegicus)
TSHR [plasma membrane] (Sus scrofa)
TSHR [plasma membrane] (Xenopus tropicalis)
Cross References
ZINC - Investigational
TSHR_HUMAN
RefSeq
XP_006720308.1
,
XP_005268096.1
,
NP_001136098.1
,
NP_000360.2
,
NP_001018046.1
OpenTargets
ENSG00000165409
ZINC - Substances
TSHR_HUMAN
GeneCards
P16473
ZINC target
P16473
PRO
P16473
ZINC - Predictions - Purchasable
TSHR_HUMAN
Orphanet
15670
HMDB Protein
HMDBP02134
PDB
3G04
,
1XUM
,
2XWT
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.581
3
UniProt:Q9NPA3 MID1IP1
1
MID1IP1 [cytosol]
(R-HSA-8867328)
0.508
2
UniProt:P21579 SYT1
7
SYT1 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-372508)
SYT1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869113)
SYT1 [plasma membrane]
(R-HSA-168786)
SYT1 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-372514)
SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]
(R-HSA-210536)
SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917741)
SYT1 [synaptic vesicle membrane]
(R-HSA-194789)
0.508
2
UniProt:P30542 ADORA1
1
ADORA1 [plasma membrane]
(R-HSA-418941)
0.508
2
© 2019
Reactome