Reactome | Luteinizing hormone receptor can bind LH

Luteinizing hormone receptor can bind LH

Stable Identifier

R-HSA-391377

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Luteinizing hormone receptor can bind LH

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Luteininzing hormone (LH, lutropin) is a dimeric glycoprotein synthesized in the anterior pituitary gland. It triggers ovulation in females and stimulates Leydig cell production of testosterone in males. It mediates its action by binding to the LH receptor (Minegishi T et al, 1990, Jia XC et al, 1991), which is found in the ovary, testes and uterus. The activated receptor couples to the G protein alpha-s subunit (Gilchrist RL et al, 1996) which activates adenylate cyclase and increases intracellular cAMP levels.

Literature References

PubMed ID	Title	Journal	Year
1922095	Expression of human luteinizing hormone (LH) receptor: interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species Oikawa, M, Bo, M, Boime, I, Hsueh, AJ, Tanaka, T, Jia, XC, Ny, T	Mol Endocrinol	1991
8702611	The luteinizing hormone/chorionic gonadotropin receptor has distinct transmembrane conductors for cAMP and inositol phosphate signals Ji, I, Gilchrist, RL, Ji, TH, Ryu, KS	J Biol Chem	1996
2244890	Cloning and sequencing of human LH/hCG receptor cDNA Minegish T [corrected to Minegishi, T, Minegishi, T, Miyamoto, K, Igarashi, M, Nakamura, K, Takakura, Y, Ibuki, Y, Hasegawa, Y	Biochem Biophys Res Commun	1990