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FSHR [plasma membrane]
Stable Identifier
R-HSA-391380
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
FSH receptor, RecName: Full=Follicle-stimulating hormone receptor; Short=FSH-R; AltName: Full=Follitropin receptor; Flags: Precursor;
GN Name=FSHR; Synonyms=LGR1;
OS Homo sapiens, FSHR_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
FSHR:Follitropin [plasma membrane] (Homo sapiens)
FSHR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
FSHR:Follitropin [plasma membrane] (Homo sapiens)
FSHR [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
FSHR:Follitropin [plasma membrane] (Homo sapiens)
FSHR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
FSHR:Follitropin [plasma membrane] (Homo sapiens)
FSHR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
FSHR:Follitropin [plasma membrane] (Homo sapiens)
FSHR [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
FSHR [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Hormone ligand-binding receptors (Homo sapiens)
Follicle-stimulating hormone receptor can bind FSH (Homo sapiens)
FSHR [plasma membrane] (Homo sapiens)
FSHR:Follitropin [plasma membrane] (Homo sapiens)
FSHR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23945 FSHR
Gene Names
FSHR, LGR1
Chain
signal peptide:1-17, chain:18-695
Reference Genes
BioGPS Gene:2492 FSHR
COSMIC (genes):FSHR FSHR
CTD Gene:2492 FSHR
dbSNP Gene:2492 FSHR
ENSEMBL:ENSG00000170820 FSHR
ENSEMBL_homo_sapiens_GENE:ENSG00000170820.12 FSHR
HGNC:3969 FSHR
KEGG Gene (Homo sapiens):2492 FSHR
Monarch:2492 FSHR
NCBI Gene:2492 FSHR
OMIM:136435 FSHR
UCSC:P23945 FSHR
Reference Transcript
RefSeq:NM_181446.2 FSHR
RefSeq:NM_000145.3 FSHR
Other Identifiers
11742249_a_at
16897427
211201_PM_at
211201_at
2492
2552471
2552472
2552473
2552474
2552477
2552478
2552483
2552488
2552489
2552497
2552510
2552511
2552512
561_at
562_g_at
8052072
A_23_P108699
A_33_P3279600
GE58042
GO:0004930
GO:0004963
GO:0005515
GO:0005886
GO:0007165
GO:0007186
GO:0007189
GO:0007283
GO:0007292
GO:0008406
GO:0008528
GO:0008584
GO:0008585
GO:0009755
GO:0010738
GO:0016020
GO:0016500
GO:0022414
GO:0023052
GO:0038023
GO:0042699
GO:0043235
GO:0048856
GO:0051897
GO:0060089
GO:0070374
GO:0071372
HMNXSV003035834
ILMN_1661616
ILMN_2333449
M65085_at
PH_hs_0000192
TC02001831.hg
g182772_3p_at
Participates
as an input of
Follicle-stimulating hormone receptor can bind FSH (Homo sapiens)
as a member of
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
as a component of
FSHR:Follitropin [plasma membrane] (Homo sapiens)
Inferred To
FSHR [plasma membrane]
(Bos taurus)
FSHR [plasma membrane]
(Canis familiaris)
FSHR [plasma membrane]
(Gallus gallus)
FSHR [plasma membrane]
(Sus scrofa)
Ghost homologue of FSHR [plasma membrane]
(Xenopus tropicalis)
fshr [plasma membrane]
(Danio rerio)
fshr-1 [plasma membrane]
(Caenorhabditis elegans)
Fshr [plasma membrane]
(Mus musculus)
Fshr [plasma membrane]
(Rattus norvegicus)
Lgr1 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000136.2
,
NP_852111.2
Guide to Pharmacology - Targets
253
OpenTargets
ENSG00000170820
ZINC - Substances
FSHR_HUMAN
ZINC target
P23945
PRO
P23945
PDB
8I2G
,
4MQW
,
1XWD
,
4AY9
,
8I2H
HPA
ENSG00000170820-FSHR
GeneCards
P23945
Ensembl
ENSP00000306780
,
ENST00000304421
,
ENSG00000170820
Pharos - Targets
P23945
ZINC - Predictions - Purchasable
FSHR_HUMAN
Orphanet
16077
HMDB Protein
HMDBP02692
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.635
4
UniProt:P36894 BMPR1A
2
BMPR1A [plasma membrane]
(R-HSA-201480)
p-4S-BMPR1A [plasma membrane]
(R-HSA-201448)
0.527
2
UniProt:B0FP48 UPK3L
0.527
2
UniProt:Q8NEN9 PDZD8
0.527
2
UniProt:O14523 C2C2L
0.527
2
UniProt:Q9H819 DJC18
0.527
2
UniProt:P61803 DAD1
1
DAD1 [endoplasmic reticulum membrane]
(R-HSA-265089)
0.527
2
UniProt:O14678 ABCD4
3
ABCD4 E583Lfs*9 [lysosomal membrane]
(R-HSA-5683320)
ABCD4 Y319C [lysosomal membrane]
(R-HSA-5683326)
ABCD4 [lysosomal membrane]
(R-HSA-5215924)
0.527
2
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