Autophosphorylation of NCAM1 bound Fyn

Stable Identifier
R-HSA-391871
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The Tyr420 residue located in the activation loop of Fyn is responsible for its enzymatic activity. Once the Tyr531 in its negative regulatory site is dephosphorylated by RPTPalpha, Fyn undergoes autophosphorylation on Tyr420 for its maximum activity.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Fyn:NCAM1:RPTP-alpha [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created