Oxoeicosanoid receptor can bind oxoeicosanoid

Stable Identifier
R-HSA-391905
Type
Reaction [binding]
Species
Homo sapiens
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Oxoeicosanoids are a family of biologically active arachidonic acid derivatives that are associated with cellular migration. These mediators are potent chemotaxins for eosinophils, monocytes and polymorphonuclear neutrophils. They act via the OXE receptor (Hosoi T et al, 2002), expressed principally in kidney, liver as well as in eosinophils, neutrophils, and lung macrophages. The most potent ligand is 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE). Activation of the receptor leads to calcium mobilization and the receptor was shown to be coupled to the G alpha i subunit (Jones CE et al, 2003).

Literature References
PubMed ID Title Journal Year
12606753 Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils

Jones, CE, Holden, S, Tenaillon, L, Bhatia, U, Seuwen, K, Tranter, P, Turner, J, Kettle, R, Bouhelal, R, Charlton, S, Nirmala, NR, Jarai, G, Finan, P

Mol Pharmacol 2003
12065583 Identification of a novel human eicosanoid receptor coupled to G(i/o)

Hosoi, T, Koguchi, Y, Sugikawa, E, Chikada, A, Ogawa, K, Tsuda, N, Suto, N, Tsunoda, S, Taniguchi, T, Ohnuki, T

J Biol Chem 2002
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