Reactome | UDP/CysLT receptor can bind cysteinyl leukotrienes

UDP/CysLT receptor can bind cysteinyl leukotrienes

Stable Identifier

R-HSA-391937

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Eicosanoid ligand-binding receptors (Homo sapiens)
        
        Leukotriene receptors (Homo sapiens)
        
        UDP/CysLT receptor can bind cysteinyl leukotrienes (Homo sapiens)

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UDP/CysLT receptor can bind cysteinyl leukotrienes

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In general, nucleotides and cysteinyl-leukotrienes (CysLTs) are unrelated signaling molecules inducing multiple effects via separate G-protein-coupled receptors: the purinoceptors and CysLT receptors. However, GPR17, an orphan receptor at intermediate phylogenetic position between P2Y and CysLT receptors, is specifically activated by both families of endogenous ligands. The orphan receptor GRR17 has been identified as a dual uracil nucleotide/cysteinyl-leukotriene receptor (Ciana P et al, 2006). Here, the ligands cys-LTs bind with the receptor and their effects are mediated by coupling to the G protein alpha i subunit (Ciana P et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
16990797	The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor Tremoli, E, Sironi, L, Ciana, P, Gelosa, P, Trincavelli, ML, Cimino, M, Parravicini, C, Abbracchio, MP, Guerrini, U, Lecca, D, Fumagalli, M, Capra, V, Martini, C, Rovati, GE, Belcredito, S, Verderio, C, Ferrario, S, Rosa, P	EMBO J	2006