TP receptor can bind thromboxane

Stable Identifier
R-HSA-391939
Type
Reaction [binding]
Species
Homo sapiens
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Thromboxane (TBXA2) is a potent stimulator for platelet aggregation and clot formation and also plays a role in vascular tone. The thromboxane receptor TP (Hirata et al. 1991) is found on the surface of vascular endothelium, platelets and in the placenta. Once bound to its ligand, TP's effects are mediated via coupling to G q/11 activation of a phosphatidylinositol-calcium second messenger system (Kinsella BT et al, 1997). TP signaling also involves G12/13 signaling; selective activation of G12/13 results in dense granule release in a mechanism that is independent of Gq/phospholipase C. The downstream mechanism for this is thought to be RhoA mediated activation of PKCdelta, as PAR-mediated dense granule release is inhibited if RhoA is blocked, and RhoA regulates PKCdelta T505 phosphorylation (Jin et al. 2009).

Literature References
PubMed ID Title Journal Year
9152406 The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha

Kinsella, BT, O'Mahony, DJ, FitzGerald, GA

J Pharmacol Exp Ther 1997
1825698 Cloning and expression of cDNA for a human thromboxane A2 receptor

Hirata, M, Hayashi, Y, Ushikubi, F, Yokota, Y, Kageyama, R, Nakanishi, S, Narumiya, S

Nature 1991
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