Once activated by PGE2, the EP2 (Regan JW et al, 1994) receptor:ligand complex can mediate downstream effects by coupling to the G protein alpha s subunit and activate adenylyl cyclase (Schwaner I et al, 1995). EP4 receptors (Bastien L et al, 1994) are present on smooth muscle cells and their effects are mediated via coupling to G protein alpha s subunit and subsequent stimulation of adenylate cyclase (Wilson RJ et al, 2004).
Wilson, RJ, Rhodes, SA, Wood, RL, Shield, VJ, Noel, LS, Gray, DW, Giles, H
Schwaner, I, Offermanns, S, Spicher, K, Seifert, R, Schultz, G
Bastien, L, Sawyer, N, Grygorczyk, R, Metters, KM, Adam, M
Regan, JW, Bailey, TJ, Pepperl, DJ, Pierce, KL, Bogardus, AM, Donello, JE, Fairbairn, CE, Kedzie, KM, Woodward, DF, Gil, DW
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