EP2 and EP4 receptors can bind PGE2

Stable Identifier
R-HSA-391940
Type
Reaction [binding]
Species
Homo sapiens
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Once activated by PGE2, the EP2 (Regan JW et al, 1994) receptor:ligand complex can mediate downstream effects by coupling to the G protein alpha s subunit and activate adenylyl cyclase (Schwaner I et al, 1995). EP4 receptors (Bastien L et al, 1994) are present on smooth muscle cells and their effects are mediated via coupling to G protein alpha s subunit and subsequent stimulation of adenylate cyclase (Wilson RJ et al, 2004).

Literature References
PubMed ID Title Journal Year
15464062 Functional pharmacology of human prostanoid EP2 and EP4 receptors

Wilson, RJ, Rhodes, SA, Wood, RL, Shield, VJ, Noel, LS, Gray, DW, Giles, H

Eur J Pharmacol 2004
7532011 Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL

Schwaner, I, Offermanns, S, Spicher, K, Seifert, R, Schultz, G

Biochim Biophys Acta 1995
8163486 Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype

Bastien, L, Sawyer, N, Grygorczyk, R, Metters, KM, Adam, M

J Biol Chem 1994
8078484 Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype

Regan, JW, Bailey, TJ, Pepperl, DJ, Pierce, KL, Bogardus, AM, Donello, JE, Fairbairn, CE, Kedzie, KM, Woodward, DF, Gil, DW

Mol Pharmacol 1994
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