Adrenaline signalling through Alpha-2 adrenergic receptor

Stable Identifier
R-HSA-392023
Type
Pathway
Species
Homo sapiens
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Adrenaline (epinephrine) signalling via the alpha-2 adrenergic receptor has many effects including inhibition of insulin release in pancreas, iinduction of glucagon release from pancreas, contraction of sphincters of the gastrointestinal tract, negative feedback processes in neuronal synapses and stimulation of platelet aggregation. This receptor preferentially couples to members of the Gi class of heterotrimeric G-proteins, leading to inhibition af adenylate cyclase and thereby decreased cAMP levels.

Literature References
PubMed ID Title Journal Year
2823383 Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor

Kobilka, BK, Matsui, H, Kobilka, TS, Yang-Feng, TL, Francke, U, Caron, MG, Lefkowitz, RJ, Regan, JW

Science 1987
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Orthologous Events
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BioModels Database
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