SOS binds Grb2 bound to pFAK:NCAM1

Stable Identifier
R-HSA-392053
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Guanine nucleotide releasing factor Sos associates with FAK bound Grb2 to activate Ras and initiate Ras-MAPK signaling. This interaction occurs between the carboxy terminal domain of SOS and the Src homology 3 (SH3) domains of GRB2.

Literature References
PubMed ID Title Journal Year
2809592 Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix

Probstmeier, R, Kuhn, K, Schachner, M

J Neurochem 1989
12700044 Cellular signalling mechanisms of neural cell adhesion molecules

Panicker, AK, Buhusi, M, Thelen, K, Maness, PF

Front Biosci 2003
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