Reactome: A Curated Pathway Database

Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

The activation of adenylyl (adenylate) cyclase (AC) results in the production of adenosine-3',5'-monophosphate i.e. cyclic AMP. Humans have 9 genes encoding membrane-associated AC and one encoding a soluble AC. Two of the classes of heterotrimeric G-proteins are named according to their effect on AC; Gs stimulates all membrane-bound ACs (the s in Gs denotes AC stimulatory); the Gi class inhibits some AC isoforms, particularly 5 and 6. Beta-gamma subunits of heterotrimeric G-proteins can also regulate AC. Ca2+/Calmodulin activates some AC isoforms (1, 8 and 3) but is inhibitory to others (5 and 6).

Literature References
Participant Of
This entity is regulated by:
Title Physical Entity Activity
adenylate cyclase activity of Adenylate cyclase (Mg2+ cofactor) [plasma membrane] Adenylate cyclase (Mg2+ cofactor) [plasma membrane] adenylate cyclase activity (0004016)
Inferred From