Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate

Stable Identifier
R-HSA-392129
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The activation of adenylyl (adenylate) cyclase (AC) results in the production of adenosine-3',5'-monophosphate i.e. cyclic AMP. Humans have 9 genes encoding membrane-associated AC and one encoding a soluble AC. Two of the classes of heterotrimeric G-proteins are named according to their effect on AC; G(s) stimulates all membrane-bound ACs (the s in G(s) denotes AC stimulatory); the G(i) class inhibits some AC isoforms, particularly 5 and 6. Beta-gamma subunits of heterotrimeric G-proteins can also regulate AC. Ca2+/Calmodulin activates some AC isoforms (1, 8 and 3) but is inhibitory to others (5 and 6).

Literature References
PubMed ID Title Journal Year
13549488 Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles

SUTHERLAND, EW, RALL, TW

J Biol Chem 1958
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
adenylate cyclase activity of G alpha (s):GTP:Adenylate cyclase [plasma membrane]
Physical Entity
Activity
This event is regulated
Inferred From
Cross References
Rhea
Authored
Reviewed
Created