Soluble guanylate cyclase converts GTP to cGMP

Stable Identifier
R-HSA-392152
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Soluble guanylate cyclase (sGC) is a heterodimeric hemoprotein that selectively binds Nitric Oxide (NO). NO binding stimulates the synthesis of cGMP, which then binds to phosphodiesterases (PDE), ion-gated channels, and cGMP-dependent protein kinases (cGK) to regulate several physiological functions including vasodilation, platelet aggregation and neurotransmission.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanylate cyclase activity of Guanylate cyclase:NO [cytosol]
Physical Entity
Activity
This event is regulated
Inferred From
Cross References
Rhea
Authored
Reviewed
Created