Reactome: A Curated Pathway Database

G alpha (i) inhibits adenylate cyclase

Stable Identifier
R-HSA-392206
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

G-proteins in the Gi class inhibit adenylate cyclase activity, decreasing the production of cAMP from ATP, which has many consequences but classically results in decreased activity of Protein Kinase A (PKA). cAMP also activates the cyclic nucleotide-gated ion channels, a process that is particularly important in olfactory cells.

Literature References
Participants
Participant Of
Inferred From