G alpha (i) inhibits adenylate cyclase

Stable Identifier
R-HSA-392206
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

G-proteins in the Gi class inhibit adenylate cyclase activity, decreasing the production of cAMP from ATP, which has many consequences but classically results in decreased activity of Protein Kinase A (PKA). cAMP also activates the cyclic nucleotide-gated ion channels, a process that is particularly important in olfactory cells.

Literature References
PubMed ID Title Journal Year
8119955 Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases

Taussig, R, Tang, WJ, Hepler, JR, Gilman, AG

J Biol Chem 1994
8327893 Inhibition of adenylyl cyclase by Gi alpha

Taussig, R, I˝iguez-Lluhi, JA, Gilman, AG

Science 1993
12058044 Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase

Dessauer, CW, Chen-Goodspeed, M, Chen, J

J. Biol. Chem. 2002
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