G alpha (i) inhibits adenylate cyclase

Stable Identifier
R-HSA-392206
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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G-proteins in the Gi class inhibit adenylate cyclase activity, decreasing the production of cAMP from ATP, which has many consequences but classically results in decreased activity of Protein Kinase A (PKA). cAMP also activates the cyclic nucleotide-gated ion channels, a process that is particularly important in olfactory cells.
Literature References
PubMed ID Title Journal Year
8327893 Inhibition of adenylyl cyclase by Gi alpha

IƱiguez-Lluhi, JA, Gilman, AG, Taussig, R

Science 1993
8119955 Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases

Gilman, AG, Hepler, JR, Tang, WJ, Taussig, R

J Biol Chem 1994
12058044 Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase

Chen-Goodspeed, M, Chen, J, Dessauer, CW

J. Biol. Chem. 2002
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