G beta:gamma signalling through PI3Kgamma

Stable Identifier
R-HSA-392451
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

PI3K gamma (PI3KG) is a heterodimer consisting of a p110 catalytic subunit associated with a regulatory p101 or p84 subunit. PI3KG is most highly expressed in neutrophils, where the p101 form predominates (approximately 95%). G beta:gamma recruits PI3KG to the plasma membrane, both activating PI3KG and providing access to its substrate PIP2, which is converted to PIP3.

Literature References
PubMed ID Title Journal Year
17916723 PI3Kgamma is a key regulator of inflammatory responses and cardiovascular homeostasis

Hawkins, PT, Stephens, LR

Science 2007
17041586 Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils

Suire, S, Condliffe, AM, Ferguson, GJ, Ellson, CD, Guillou, H, Davidson, K, Welch, H, Coadwell, J, Turner, M, Chilvers, ER, Hawkins, PT, Stephens, L

Nat Cell Biol 2006
Participants
Participant Of
Orthologous Events
Cross References
Authored
Reviewed
Created