Rap1 signal termination by Rap1GAPs

Stable Identifier
R-HSA-392513
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Rap1 signalling is terminated by the hydrolysis of bound GTP to GDP. The intrinsic GTPase activity of Rap1 is greatly enhanced by GTP-ase activating proteins (GAPs).

Literature References
PubMed ID Title Journal Year
9346962 Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product

Kurachi, H, Wada, Y, Tsukamoto, N, Maeda, M, Kubota, H, Hattori, M, Iwai, K, Minato, N

J Biol Chem 1997
1846040 Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells

Polakis, PG, Rubinfeld, B, Evans, T, McCormick, F

Proc Natl Acad Sci U S A 1991
15632203 Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets

Schultess, J, Danielewski, O, Smolenski, AP

Blood 2005
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
GTPase activator activity of Rap1 GTPase-activating proteins [cytosol]
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This event is regulated
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