Reactome: A Curated Pathway Database

L1 binds to AP-2 Clathrin complex

Stable Identifier
R-HSA-392748
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

L1 in the C-domain membrane is internalized via clathrin mediated endocytosis. The assembly of clathrin coats at the plasma membrane depends on the adaptor complex AP-2 which is composed of two large chains (alpha and beta1 or beta2 adaptin), one medium (mu2) chain, and one small chain (sigma2). When dephosphorylated, the sorting signal/endocytic motif YRSLE sequence enables L1 to directly bind the mu2 subunit of AP-2, and concentrates L1 molecules in clathrin coated areas of the plasma membrane.

Literature References
Participants
Participant Of
Orthologous Events