Transport of L1 into endosomes

Stable Identifier
R-HSA-392749
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Membrane bound L1 is internalized through clathrin coated vesicles and is endocytosed into recycling endosomes. Moreover, L1 promotes co-endocytosis of beta1 integrins with which it is associated into early endosomes.

Literature References
PubMed ID Title Journal Year
10804209 Recycling of the cell adhesion molecule L1 in axonal growth cones

Kamiguchi, H, Lemmon, V

J Neurosci 2000
9651214 The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway

Kamiguchi, H, Long, KE, Pendergast, M, Schaefer, AW, Rapoport, I, Kirchhausen, T, Lemmon, V

J Neurosci 1998
16330023 Endocytosis of beta1 integrins is an early event in migration promoted by the cell adhesion molecule L1

Panicker, AK, Buhusi, M, Erickson, A, Maness, PF

Exp Cell Res 2006
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