Reactome: A Curated Pathway Database

Phosphorylation of L1 by CK-II

Stable Identifier
R-HSA-392752
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CKII phosphorylates L1CAM at serine 1181, just after the AP-2 recognition site (Y1176RSLE motif). CKII-dependent phosphorylation of S1181 has been shown to regulate trafficking of the internalized L1 and subsequent axon growth.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
kinase activity of Casein kinase II [cytosol] Casein kinase II [cytosol] kinase activity (0016301)
Orthologous Events