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TUBB4A unfolded [cytosol]
Stable Identifier
R-HSA-392778
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
unfolded beta tubulin 5
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (Homo sapiens)
Formation of tubulin folding intermediates by CCT/TriC (Homo sapiens)
ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex (Homo sapiens)
CCT/TRiC:ADP:non-native tubulin [cytosol] (Homo sapiens)
Unfolded alpha/beta tubulin [cytosol] (Homo sapiens)
TUBB4A unfolded [cytosol] (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
Unfolded alpha/beta tubulin [cytosol] (Homo sapiens)
TUBB4A unfolded [cytosol] (Homo sapiens)
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
Unfolded alpha/beta tubulin [cytosol] (Homo sapiens)
TUBB4A unfolded [cytosol] (Homo sapiens)
Prefoldin mediated transfer of substrate to CCT/TriC (Homo sapiens)
Actin/tubulin:prefoldin complex associates with CCT/TriC (Homo sapiens)
Prefoldin-associated actin/tubulin [cytosol] (Homo sapiens)
unfolded actin/tubulin [cytosol] (Homo sapiens)
TUBB4A unfolded [cytosol] (Homo sapiens)
actin/tubulin-bound CCT/TRiC:ADP [cytosol] (Homo sapiens)
unfolded actin/tubulin [cytosol] (Homo sapiens)
TUBB4A unfolded [cytosol] (Homo sapiens)
unfolded actin/tubulin associates with prefoldin (Homo sapiens)
Prefoldin-associated actin/tubulin [cytosol] (Homo sapiens)
unfolded actin/tubulin [cytosol] (Homo sapiens)
TUBB4A unfolded [cytosol] (Homo sapiens)
unfolded actin/tubulin [cytosol] (Homo sapiens)
TUBB4A unfolded [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04350 TUBB4A
Gene Names
TUBB4A, TUBB4, TUBB5
Chain
chain:1-444
Reference Genes
BioGPS Gene:10382 TUBB4A
COSMIC (genes):TUBB4A TUBB4A
CTD Gene:10382 TUBB4A
dbSNP Gene:10382 TUBB4A
ENSEMBL:ENSG00000104833 TUBB4A
ENSEMBL_homo_sapiens_GENE:ENSG00000104833.12 TUBB4A
HGNC:20774 TUBB4A
KEGG Gene (Homo sapiens):10382 TUBB4A
Monarch:10382 TUBB4A
NCBI Gene:10382 TUBB4A
OMIM:602662 TUBB4A
UCSC:P04350 TUBB4A
Reference Transcript
RefSeq:NM_001289129.1 TUBB4A
RefSeq:NM_001289130.1 TUBB4A
RefSeq:NM_001289131.1 TUBB4A
RefSeq:NM_001289123.1 TUBB4A
RefSeq:NM_001289127.1 TUBB4A
RefSeq:NM_006087.3 TUBB4A
Other Identifiers
10382
11744256_a_at
11744257_s_at
11748829_a_at
11749715_s_at
11751118_x_at
16867756
212664_PM_at
212664_at
213476_3p_x_at
213476_PM_x_at
213476_x_at
33678_i_at
3847960
3847961
3847962
3847963
3847964
3847965
3847966
3847967
3847968
3847969
3847971
3847972
3847973
3847975
3847976
38699_at
4050505
429_f_at
8033233
A_23_P113656
A_23_P50338
GE81597
GO:0000166
GO:0000226
GO:0000278
GO:0003824
GO:0003924
GO:0005198
GO:0005200
GO:0005509
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005874
GO:0005929
GO:0005930
GO:0007010
GO:0007017
GO:0015630
GO:0016787
GO:0031115
GO:0033269
GO:0042995
GO:0043025
GO:0043209
GO:0043226
GO:0045171
GO:0046872
GO:0065003
GO:0070062
GO:0072686
HMNXSV003056538
Hs.110837.0.S2_3p_at
ILMN_1682459
PH_hs_0006099
TC19001099.hg
X00734_at
Participates
as a member of
Unfolded alpha/beta tubulin [cytosol] (Homo sapiens)
unfolded actin/tubulin [cytosol] (Homo sapiens)
Other forms of this molecule
TUBB4A [cytosol]
TUBB4A [axonemal microtubule]
Polyglutamyl-TUBB4A [cytosol]
Polyglycyl-TUBB4A [cytosol]
TUBB4A folding intermediate [cytosol]
Cross References
RefSeq
NP_001276052.1
,
NP_001276059.1
,
NP_001276058.1
,
NP_001276060.1
,
NP_006078.2
,
NP_001276056.1
OpenTargets
ENSG00000104833
GeneCards
P04350
HPA
ENSG00000104833-TUBB4A
Ensembl
ENSP00000264071
,
ENST00000264071
,
ENSG00000104833
PRO
P04350
Pharos - Targets
P04350
Orphanet
21207
HMDB Protein
HMDBP08047
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.67
6
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
10
UniProt:P36404 ARL2
2
ARL2 [cytosol]
(R-HSA-5216230)
ARL2 [mitochondrial matrix]
(R-HSA-5250216)
0.527
3
UniProt:P54764 EPHA4
2
EPHA4 [plasma membrane]
(R-HSA-2682325)
p-Y596,Y602-EPHA4 [plasma membrane]
(R-HSA-3928352)
0.527
2
UniProt:Q07954 LRP1
2
LRP1 [plasma membrane]
(R-HSA-1454844)
LRP1 [endocytic vesicle membrane]
(R-HSA-2230981)
0.527
2
UniProt:P07437 TUBB
3
TUBB [cytosol]
(R-HSA-9020816)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [extracellular region]
(R-HSA-380317)
0.527
2
UniProt:P22736 NR4A1
2
p-S351-NR4A1 [nucleoplasm]
(R-HSA-199846)
NR4A1 [nucleoplasm]
(R-HSA-199831)
0.524
2
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