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TUBA4A folding intermediate [cytosol]
Stable Identifier
R-HSA-392800
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
alpha tubulin -1 folding intermediate
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (Homo sapiens)
Formation of tubulin folding intermediates by CCT/TriC (Homo sapiens)
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)
tubulin-GTP folding intermediate [cytosol] (Homo sapiens)
alpha/beta tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA4A folding intermediate [cytosol] (Homo sapiens)
Post-chaperonin tubulin folding pathway (Homo sapiens)
Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA4A folding intermediate [cytosol] (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA4A folding intermediate [cytosol] (Homo sapiens)
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA4A folding intermediate [cytosol] (Homo sapiens)
beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E : Cofactor C [cytosol] (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA4A folding intermediate [cytosol] (Homo sapiens)
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi (Homo sapiens)
beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E : Cofactor C [cytosol] (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA4A folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B (Homo sapiens)
Cofactor B:GTP-alpha tubulin [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA4A folding intermediate [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA4A folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin:GTP + Cofactor E -> alpha-tubulin:GTP:Cofactor E (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA4A folding intermediate [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA4A folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin:GTP:Cofactor B +Cofactor E -> alpha-tubulin:GTP: Cofactor E +Cofactor B (Homo sapiens)
Cofactor B:GTP-alpha tubulin [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA4A folding intermediate [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA4A folding intermediate [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P68366 TUBA4A
Gene Names
TUBA4A, TUBA1
Chain
chain:1-448
Reference Genes
BioGPS Gene:7277 TUBA4A
COSMIC (genes):TUBA4A TUBA4A
CTD Gene:7277 TUBA4A
dbSNP Gene:7277 TUBA4A
ENSEMBL:ENSG00000127824 TUBA4A
HGNC:12407 TUBA4A
KEGG Gene (Homo sapiens):7277 TUBA4A
Monarch:7277 TUBA4A
NCBI Gene:7277 TUBA4A
OMIM:191110 TUBA4A
UCSC:P68366 TUBA4A
Reference Transcript
RefSeq:NM_006000.2 TUBA4A
RefSeq:NM_001278552.1 TUBA4A
Other Identifiers
0005720136
11716459_at
11716460_x_at
212242_at
2528412
2528417
2528418
2600069
2600070
2600073
2600075
2600076
2600080
2600081
330_s_at
36591_at
61786_at
7277
8059177
A_23_P154065
A_23_P154070
GE505003
GE86661
GO:0000086
GO:0000166
GO:0000226
GO:0000278
GO:0002576
GO:0003674
GO:0003924
GO:0005198
GO:0005200
GO:0005515
GO:0005525
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005829
GO:0005856
GO:0005874
GO:0006810
GO:0007010
GO:0007017
GO:0007049
GO:0008150
GO:0010389
GO:0015630
GO:0016192
GO:0019899
GO:0019901
GO:0022607
GO:0043167
GO:0043226
GO:0070062
GO:0097711
HMNXSV003013201
HMNXSV003042752
Hs.75318.0.S1_3p_at
Hs.75318.0.S1_3p_x_at
ILMN_1784300
PH_hs_0028966
PH_hs_0031317
TC02002793.hg
X06956_at
Participates
as a member of
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
Other forms of this molecule
TUBA4A [cytosol]
TUBA4A [axonemal microtubule]
TUBA4A [extracellular region]
Polyglutamyl-TUBA4A [cytosol]
L-isoglutamyl polyglycyl-TUBA4A [cytosol]
TUBA4A unfolded [cytosol]
Ac K40 TUBA4A [axonemal microtubule]
AcK-TUBA4A [cytosol]
Cross References
RefSeq
NP_001265481.1
,
NP_005991.1
Target Pathogen
5b354852be737e166372e783
,
57c0987dbe737e1cc0a980a0
,
57c0987dbe737e1cc0a9809f
,
57c09dd1be737e1cc0a98f68
,
57c0840cbe737e1cc0a94465
OpenTargets
ENSG00000127824
GeneCards
P68366
HPA
ENSG00000127824-TUBA4A
Ensembl
ENST00000392088
,
ENSP00000248437
,
ENSG00000127824
,
ENSP00000375938
,
ENST00000248437
PRO
P68366
Orphanet
25006
HMDB Protein
HMDBP08598
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30622 CLIP1
1
CLIP1 [cytosol]
(R-HSA-377732)
0.618
3
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P36507 MAP2K2
12
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
MAP2K2 C125S [cytosol]
(R-HSA-9652070)
MAP2K2 P128Q [cytosol]
(R-HSA-9652082)
MAP2K2 V35M [cytosol]
(R-HSA-9652086)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
MAP2K2 [cytosol]
(R-HSA-59504)
MAP2K2 N126D [cytosol]
(R-HSA-9652079)
MAP2K2 L46F [cytosol]
(R-HSA-9652076)
MAP2K2 F57C [cytosol]
(R-HSA-9652073)
MAP2K2 Y134C [cytosol]
(R-HSA-9652089)
0.527
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.527
5
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.527
2
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