Activation of EPACs by cAMP

Stable Identifier
R-HSA-392834
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

EPACs (exchange proteins directly activated by cAMP) are Rap1 GEFs that are activated by direct binding of cAMP (cyclic adenosine monophosphate). cAMP-GEFI (EPAC1) is widely expressed, while cAMP-GEFII (EPAC2) is enriched in brain and adrenal tissue. Both are selective for Rap1. A role of EPACs has been proposed for Rap1-dependent cell adhesion to laminin in both epithelial and red blood cells, and in the regulation of vascular endothelial barrier function.

Literature References
PubMed ID Title Journal Year
9789079 A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

Kawasaki, H, Springett, GM, Toki, S, Canales, JJ, Harlan, P, Blumenstiel, JP, Chen, EJ, Bany, IA, Mochizuki, N, Ashbacher, A, Matsuda, M, Housman, DE, Graybiel, AM

Proc Natl Acad Sci U S A 1998
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed
Created
Cite Us!