Rap1 sequesters Raf1 to inhibit ERK cascade

Stable Identifier
R-HSA-392835
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Rap1 sequesters Raf1 to inhibit ERK cascade
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Active Rap1 binds but does not activate Raf-1, preventing Raf-1 from participating in the Ras/ERK pathway.
Literature References
PubMed ID Title Journal Year
8253074 RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts

Cook, SJ, Rubinfeld, B, Albert, I, McCormick, F

EMBO J 1993
9115221 Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with ras-dependent activation of Raf-1

Hu, CD, Kariya, K, Kotani, G, Shirouzu, M, Yokoyama, S, Kataoka, T

J Biol Chem 1997
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Authored
Akkerman, JW  (2009-06-03)
Reviewed
Heemskerk, JW  (2010-09-01)
Created
Jupe, S  (2009-03-09)
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