Reactome | p-Y383-GIT1 [cytosol]

p-Y383-GIT1 [cytosol]

Stable Identifier

R-HSA-3928463

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

phospho-GIT1

Locations in the PathwayBrowser for interactor UniProt:P49023

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External Reference Information

External Reference

UniProt:Q9Y2X7 GIT1

Gene Names

GIT1

Chain

chain:1-761

Reference Genes

BioGPS Gene:28964 GIT1

COSMIC (genes):GIT1 GIT1

CTD Gene:28964 GIT1

dbSNP Gene:28964 GIT1

ENSEMBL:ENSG00000108262 GIT1

HGNC:4272 GIT1

KEGG Gene (Homo sapiens):28964 GIT1

Monarch:28964 GIT1

NCBI Gene:28964 GIT1

OMIM:608434 GIT1

UCSC:Q9Y2X7 GIT1

Reference Transcript

Other Identifiers

0004230372

11717653_a_at

11752140_x_at

11754464_x_at

16842999

218030_at

28964

3751542

3751543

3751544

3751546

3751547

3751549

3751550

3751551

3751552

3751553

3751554

3751556

3751557

3751558

3751559

3751560

3751561

3751563

3751566

3751567

3751568

3751569

3751571

3751572

3751576

3751577

43805_f_at

65952_at

8013923

A_23_P100912

A_24_P347946

A_33_P3401673

GE58546

GO:0003674

GO:0005096

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005829

GO:0005925

GO:0006810

GO:0007049

GO:0007165

GO:0007267

GO:0007420

GO:0007626

GO:0008150

GO:0008277

GO:0016020

GO:0016192

GO:0030154

GO:0030234

GO:0032465

GO:0043167

GO:0043226

GO:0043547

GO:0044305

GO:0044877

GO:0046872

GO:0048013

GO:0048666

GO:0048856

GO:0050877

GO:0051301

GO:0061743

GO:0099171

GO:2000300

HMNXSV003048269

ILMN_1733155

PH_hs_0024106

TC17001320.hg

g7661711_3p_at

g7661711_3p_x_at

Participates

as an output of

SFKs phosphorylate GIT1 (Homo sapiens)

as an input of

EFNB:GRB4 binds GIT1 (Homo sapiens)

as a component of

EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)

Other forms of this molecule

GIT1 [cytosol]

Inferred To

phospho-git1 [cytosol] (Danio rerio)

phospho-GIT1 [cytosol] (Bos taurus)

phospho-GIT1 [cytosol] (Canis familiaris)

phospho-GIT1 [cytosol] (Gallus gallus)

phospho-GIT1 [cytosol] (Sus scrofa)

phospho-Git1 [cytosol] (Mus musculus)

phospho-Git1 [cytosol] (Rattus norvegicus)

phospho-git-1 [cytosol] (Caenorhabditis elegans)

phospho-Git [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O4'-phospho-L-tyrosine at 383

Coordinate

383

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001078923.1, NP_054749.2

OpenTargets

ENSG00000108262

HPA

ENSG00000108262-GIT1

GeneCards

Q9Y2X7

Ensembl

ENSP00000378338, ENST00000225394, ENSP00000225394, ENST00000394869, ENSG00000108262

PRO

Q9Y2X7

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13153 PAK1	6	p-S144-PAK1 [cytosol] (R-HSA-451339) Active PAK1 [cytosol] (R-HSA-8964622) PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.744	5
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.702	4
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.669	4
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709)	0.669	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.659	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.602	10
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.564	3
UniProt:O60925 PFDN1	1	PFDN1 [cytosol] (R-HSA-379541)	0.553	2
UniProt:P41220 RGS2	1	RGS2 [plasma membrane] (R-HSA-939787)	0.553	2
UniProt:P30519 HMOX2	3	HMOX2 [specific granule membrane] (R-HSA-6799628) HMOX2 [plasma membrane] (R-HSA-6799676) HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391)	0.553	2
UniProt:Q9H7E9 CH033			0.553	2
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.553	2
UniProt:Q99728 BARD1	13	BARD1 C71Y [nucleoplasm] (R-HSA-9700808) BARD1 G623E [nucleoplasm] (R-HSA-9699135) BARD1 C53W [nucleoplasm] (R-HSA-9700807) BARD1 G623W [nucleoplasm] (R-HSA-9699148) BARD1 W34R [nucleoplasm] (R-HSA-9699166) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846) K6PolyUb,p-T714,T734-BARD1 [nucleoplasm] (R-HSA-9707286) K6PolyUb-BARD1 [nucleoplasm] (R-HSA-9701024) BARD1 [nucleoplasm] (R-HSA-5659775) BARD1 C83G [nucleoplasm] (R-HSA-9699139) BARD1 C50G [nucleoplasm] (R-HSA-9699137) BARD1 L44R [nucleoplasm] (R-HSA-9699126) BARD1 H68Y [nucleoplasm] (R-HSA-9699151)	0.508	2
UniProt:Q9P2H0 CE126			0.508	2
UniProt:Q5T3J3 LRIF1			0.508	2
UniProt:Q12873 CHD3	2	SUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372) CHD3 [nucleoplasm] (R-HSA-4657012)	0.508	2
UniProt:P49024 PAXI			0.499	3
UniProt:P25098 GRK2	4	ADRBK1 [cilium] (R-HSA-5632504) p-S29-ADRBK1 [cytosol] (R-HSA-9645318) GRK2 [plasma membrane] (R-HSA-50270) p-S29-ADRBK1 [plasma membrane] (R-HSA-111969)	0.463	5

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