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p-S144,T423-PAK1 [plasma membrane]
Stable Identifier
R-HSA-3928472
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
PAK1 autophosphorylates (Homo sapiens)
RAC1-GTP:p-S144,T423-PAK1 [plasma membrane] (Homo sapiens)
p-S144,T423-PAK1 [plasma membrane] (Homo sapiens)
Ephrin signaling (Homo sapiens)
PAKs autophosphorylate (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
p-PAK1/3, 2 [plasma membrane] (Homo sapiens)
p-S144,T423-PAK1 [plasma membrane] (Homo sapiens)
PAKs phosphorylate MLC (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
p-PAK1/3, 2 [plasma membrane] (Homo sapiens)
p-S144,T423-PAK1 [plasma membrane] (Homo sapiens)
p-PAK1/3, 2 [plasma membrane] (Homo sapiens)
p-S144,T423-PAK1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13153 PAK1
Gene Names
PAK1
Chain
initiator methionine:1, chain:2-545
Reference Genes
BioGPS Gene:5058 PAK1
COSMIC (genes):PAK1 PAK1
CTD Gene:5058 PAK1
dbSNP Gene:5058 PAK1
ENSEMBL:ENSG00000149269 PAK1
HGNC:8590 PAK1
KEGG Gene (Homo sapiens):5058 PAK1
Monarch:5058 PAK1
NCBI Gene:5058 PAK1
OMIM:602590 PAK1
UCSC:Q13153 PAK1
Reference Transcript
RefSeq:XM_011545084.2 PAK1
RefSeq:XM_017017847.1 PAK1
RefSeq:XM_017017846.1 PAK1
RefSeq:XM_017017848.1 PAK1
RefSeq:NM_001128620.1 PAK1
RefSeq:XM_017017849.1 PAK1
RefSeq:XM_011545080.2 PAK1
RefSeq:XM_017017850.1 PAK1
RefSeq:NM_002576.4 PAK1
RefSeq:XM_011545082.2 PAK1
RefSeq:XM_011545083.2 PAK1
RefSeq:XM_011545081.2 PAK1
Other Identifiers
0004810181
04150+2.7.11.1
04151+2.7.11.1
04714+2.7.11.1
04926+2.7.11.1
05163+2.7.11.1
05165+2.7.11.1
05170+2.7.11.1
11720103_a_at
11720104_a_at
1557_at
1558_g_at
1565772_at
16742454
1F3M
1YHV
1YHW
1ZSG
209615_s_at
226507_at
230100_x_at
2HY8
2QME
3382862
3382863
3382864
3382865
3382866
3382867
3382869
3382871
3382873
3382874
3382876
3382878
3382879
3382881
3382884
3382886
3382891
3382893
3382895
3382896
3382900
3382909
3565
3DVP
3FXZ
3FY0
3Q4Z
3Q52
3Q53
43052_at
43053_g_at
47835_at
4DAW
4EQC
4O0R
4O0T
4P90
4ZJI
4ZJJ
4ZLO
4ZY4
4ZY5
4ZY6
5058
5312
5DEW
5DEY
5DFP
5IME
5KBQ
5KBR
60859_at
6B16
7950578
A0A024R5P0
A_23_P75989
A_33_P3288609
A_33_P3784253
AAA65441
AAC24716
AAC50590
AAI09300
AF071884
AP000486
AP003680
B3KNX7
BC109299
CAB005312
CCDS44687
CCDS8250
CH471076
E9PJF8
E9PKH9
E9PM17
E9PMP2
E9PQW5
E9PRP6
EAW75026
EAW75027
EAW75029
ENSG00000149269
ENSP00000278568
ENSP00000348696
ENST00000278568
ENST00000278568.8
ENST00000356341
ENST00000356341.7
EntrezGene:5058
EntrezGene:PAK1
g1256421_3p_a_at
GE59021
GE86276
GO:0000166
GO:0000902
GO:0001666
GO:0001726
GO:0001934
GO:0002223
GO:0002376
GO:0003674
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005518
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005911
GO:0005925
GO:0006338
GO:0006464
GO:0006468
GO:0006605
GO:0006810
GO:0006887
GO:0006915
GO:0006950
GO:0006974
GO:0007010
GO:0007155
GO:0007165
GO:0008150
GO:0008152
GO:0008219
GO:0008283
GO:0008284
GO:0010033
GO:0010763
GO:0014704
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0019899
GO:0019901
GO:0021549
GO:0022607
GO:0023014
GO:0030010
GO:0030018
GO:0030027
GO:0030054
GO:0030154
GO:0030335
GO:0030424
GO:0030425
GO:0031098
GO:0031116
GO:0031295
GO:0031532
GO:0031965
GO:0032147
GO:0032587
GO:0032869
GO:0032956
GO:0032991
GO:0033138
GO:0033148
GO:0038095
GO:0038096
GO:0040007
GO:0040011
GO:0042060
GO:0042995
GO:0043167
GO:0043226
GO:0043408
GO:0043507
GO:0045773
GO:0046628
GO:0046777
GO:0048012
GO:0048013
GO:0048365
GO:0048754
GO:0048812
GO:0048856
GO:0048870
GO:0050770
GO:0050852
GO:0051276
GO:0051496
GO:0060244
GO:0061052
GO:0065003
GO:0071437
GO:0090314
GO:1904707
GO:1904754
HGNC:8590
HPA003565
Hs.23295.0.A1_3p_at
Hs.329996.0.A1_3p_s_at
ILMN_1767365
IPR000095
IPR000719
IPR008271
IPR011009
IPR017441
IPR033923
IPR036936
MIM:602590
MIM:618158
NM_001128620
NM_002576
NP_001122092
NP_002567
PAK1
PAK1-201
PAK1-202
PF00069
PF00786
PH_hs_0003990
SM00220
SM00285
TC11002123.hg
TC11003261.hg
U24152
U24152_at
U51120
UPI000013DB7F
UPI000013ED74
XM_011545080
XM_011545081
XM_011545082
XM_011545083
XM_011545084
XM_017017846
XM_017017847
XM_017017848
XM_017017849
XM_017017850
XM_024448557
XM_024448558
XM_024448559
XM_024448560
XM_024448561
XM_024448562
XM_024448563
XM_024448564
XP_011543382
XP_011543383
XP_011543384
XP_011543385
XP_011543386
XP_016873335
XP_016873336
XP_016873337
XP_016873338
XP_016873339
XP_024304325
XP_024304326
XP_024304327
XP_024304328
XP_024304329
XP_024304330
XP_024304331
XP_024304332
Participant Of
hasComponent
RAC1-GTP:p-S144,T423-PAK1 [plasma membrane]
hasMember
p-PAK1/3, 2 [plasma membrane]
Other forms of this molecule
Active PAK1 [cytosol]
p-S144-PAK1 [cytosol]
PAK1 [plasma membrane]
PAK1 [cytosol]
p-S144,T423-PAK1 [cytosol]
Inferred To
phospho-p-S144,T423-PAK1 [plasma membrane] (Bos taurus)
phospho-p-S144,T423-PAK1 [plasma membrane] (Caenorhabditis elegans)
phospho-p-S144,T423-PAK1 [plasma membrane] (Canis familiaris)
phospho-p-S144,T423-PAK1 [plasma membrane] (Danio rerio)
phospho-p-S144,T423-PAK1 [plasma membrane] (Dictyostelium discoideum)
phospho-p-S144,T423-PAK1 [plasma membrane] (Drosophila melanogaster)
phospho-p-S144,T423-PAK1 [plasma membrane] (Gallus gallus)
phospho-p-S144,T423-PAK1 [plasma membrane] (Mus musculus)
phospho-p-S144,T423-PAK1 [plasma membrane] (Rattus norvegicus)
phospho-p-S144,T423-PAK1 [plasma membrane] (Sus scrofa)
phospho-p-S144,T423-PAK1 [plasma membrane] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 144
Coordinate
144
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 423
Coordinate
423
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_011543382.1
,
XP_016873337.1
,
XP_016873338.1
,
XP_011543386.1
,
NP_002567.3
,
XP_016873339.1
,
NP_001122092.1
,
XP_011543385.1
,
XP_016873336.1
,
XP_011543383.1
,
XP_016873335.1
,
XP_011543384.1
ZINC - World Drugs
PAK1_HUMAN
OpenTargets
ENSG00000149269
ZINC - FDA approved
PAK1_HUMAN
ZINC - Substances
PAK1_HUMAN
ZINC target
Q13153
ZINC - Biogenic
PAK1_HUMAN
PRO
Q13153
PDB
3Q53
,
5DFP
,
4O0T
,
4ZY4
,
1ZSG
,
4ZLO
,
1YHW
,
2HY8
,
3FY0
,
3Q4Z
,
4O0R
,
3Q52
,
3FXZ
,
1F3M
,
4P90
,
4ZJJ
,
4DAW
,
4ZJI
,
3DVP
,
2QME
,
1YHV
,
5KBR
,
5DEY
,
5KBQ
,
5IME
,
4ZY6
,
6B16
,
5DEW
,
4EQC
,
4ZY5
ZINC - Investigational
PAK1_HUMAN
GeneCards
Q13153
ZINC - Predictions - Purchasable
PAK1_HUMAN
HMDB Protein
HMDBP08499
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.976
27
UniProt:P60953 CDC42
3
CDC42 [plasma membrane]
(R-HSA-449545)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
0.944
15
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.935
9
GTP [ChEBI:15996]
13
GTP [early endosome membrane]
(R-ALL-2130170)
GTP [cilium]
(R-ALL-5617813)
GTP [lysosomal membrane]
(R-ALL-2213216)
GTP [platelet dense granule lumen]
(R-ALL-114625)
GTP [cytoplasmic vesicle membrane]
(R-ALL-1996291)
GTP [extracellular region]
(R-ALL-114626)
GTP [Golgi lumen]
(R-ALL-8851242)
GTP [endocytic vesicle lumen]
(R-ALL-8851508)
GTP [ER to Golgi transport vesicle membrane]
(R-ALL-983318)
GTP [mitochondrial matrix]
(R-ALL-113573)
GTP [Golgi membrane]
(R-ALL-1806221)
GTP [nucleoplasm]
(R-ALL-113571)
GTP [cytosol]
(R-ALL-29438)
0.778
4
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.766
6
UniProt:P21127 CDK11B
1
CDK11B [cytosol]
(R-HSA-380451)
0.69
4
UniProt:P63001 Rac1
7
RAC1 [ficolin-1-rich granule membrane]
(R-MMU-6804802)
RAC1 [endoplasmic reticulum membrane]
(R-MMU-5672076)
RAC1 [secretory granule membrane]
(R-MMU-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-MMU-2316446)
Rac1 [plasma membrane]
(R-MMU-2316449)
RAC1 [cytosol]
(R-MMU-442615)
Rac1 [plasma membrane]
(R-MMU-421093)
0.688
3
UniProt:P60766 Cdc42
3
Cdc42 [plasma membrane]
(R-MMU-448841)
CDC42 [endoplasmic reticulum membrane]
(R-MMU-5672086)
CDC42 [cytosol]
(R-MMU-442630)
0.688
3
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.669
3
UniProt:Q8N1N5 CRPAK
0.645
6
UniProt:P63000-1 RAC1
0.641
3
UniProt:P53667 LIMK1
3
p-T508-LIMK1 [cytosol]
(R-HSA-399816)
LIMK1 [cytosol]
(R-HSA-397785)
p-S,T508-LIMK1 [cytosol]
(R-HSA-419610)
0.619
5
UniProt:P62999 RAC1
0.617
3
UniProt:Q7L0Q8 RHOU
2
RHOU [cytosol]
(R-HSA-194901)
RHOU [plasma membrane]
(R-HSA-194914)
0.589
3
UniProt:Q5PP90 Q5PP90
0.558
2
UniProt:Q15052 ARHGEF6
1
ARHGEF6 [cytosol]
(R-HSA-195017)
0.547
2
UniProt:P60953-2 CDC42
0.547
2
UniProt:Q15365 PCBP1
1
PCBP1 [nucleoplasm]
(R-HSA-71919)
0.524
2
UniProt:Q05513-1 PRKCZ
0.499
5
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