Reactome | p-S144,T423-PAK1 [plasma membrane]

p-S144,T423-PAK1 [plasma membrane]

Stable Identifier

R-HSA-3928472

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

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External Reference Information

External Reference

UniProt:Q13153 PAK1

Gene Names

PAK1

Chain

initiator methionine:1, chain:2-545

Reference Genes

BioGPS Gene:5058 PAK1

COSMIC (genes):PAK1 PAK1

CTD Gene:5058 PAK1

dbSNP Gene:5058 PAK1

ENSEMBL:ENSG00000149269 PAK1

HGNC:8590 PAK1

KEGG Gene (Homo sapiens):5058 PAK1

Monarch:5058 PAK1

NCBI Gene:5058 PAK1

OMIM:602590 PAK1

UCSC:Q13153 PAK1

Reference Transcript

Other Identifiers

0004810181

11720103_a_at

11720104_a_at

1557_at

1558_g_at

1565772_at

16742454

209615_s_at

226507_at

230100_x_at

3382862

3382863

3382864

3382865

3382866

3382867

3382869

3382871

3382873

3382874

3382876

3382878

3382879

3382881

3382884

3382886

3382891

3382893

3382895

3382896

3382900

3382909

43052_at

43053_g_at

47835_at

5058

60859_at

7950578

A_23_P75989

A_33_P3288609

A_33_P3784253

GE59021

GE86276

GO:0000166

GO:0000902

GO:0001666

GO:0001726

GO:0001934

GO:0002223

GO:0002376

GO:0003674

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005518

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005911

GO:0005925

GO:0006338

GO:0006464

GO:0006468

GO:0006605

GO:0006810

GO:0006887

GO:0006915

GO:0006950

GO:0006974

GO:0007010

GO:0007155

GO:0007165

GO:0008092

GO:0008150

GO:0008152

GO:0008219

GO:0008283

GO:0008284

GO:0010033

GO:0010763

GO:0014704

GO:0015031

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0019899

GO:0019901

GO:0021549

GO:0022607

GO:0030010

GO:0030018

GO:0030027

GO:0030054

GO:0030154

GO:0030335

GO:0030424

GO:0030425

GO:0031098

GO:0031116

GO:0031267

GO:0031295

GO:0031532

GO:0031965

GO:0032147

GO:0032587

GO:0032869

GO:0032956

GO:0032991

GO:0033138

GO:0033148

GO:0038095

GO:0038096

GO:0040007

GO:0040011

GO:0042060

GO:0042802

GO:0042995

GO:0043015

GO:0043167

GO:0043226

GO:0043507

GO:0045773

GO:0046628

GO:0046777

GO:0048012

GO:0048013

GO:0048754

GO:0048812

GO:0048856

GO:0048870

GO:0050770

GO:0050852

GO:0051276

GO:0051496

GO:0060244

GO:0061052

GO:0065003

GO:0090063

GO:0090314

GO:0106310

GO:0106311

GO:1904707

GO:1904754

HMNXSV003022832

HMNXSV003030470

Hs.23295.0.A1_3p_at

Hs.329996.0.A1_3p_s_at

ILMN_1767365

PH_hs_0003990

TC11002123.hg

TC11003261.hg

U24152_at

g1256421_3p_a_at

Participates

as a component of

RAC1-GTP:p-S144,T423-PAK1 [plasma membrane] (Homo sapiens)

as a member of

p-PAK1/3, 2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

Active PAK1 [cytosol]

p-S144-PAK1 [cytosol]

PAK1 [plasma membrane]

PAK1 [cytosol]

p-S144,T423-PAK1 [cytosol]

Inferred To

phospho-Pak1 [plasma membrane] (Mus musculus)

phospho-Pak1 [plasma membrane] (Rattus norvegicus)

phospho-pakC [plasma membrane] (Dictyostelium discoideum)

phospho-PAK1 [plasma membrane] (Bos taurus)

phospho-PAK1 [plasma membrane] (Canis familiaris)

phospho-PAK1 [plasma membrane] (Gallus gallus)

phospho-PAK1 [plasma membrane] (Sus scrofa)

phospho-pak1 [plasma membrane] (Danio rerio)

phospho-Pak [plasma membrane] (Drosophila melanogaster)

phospho-pak-1 [plasma membrane] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 144

Coordinate

144

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 423

Coordinate

423

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_011543385.1, NP_002567.3, XP_016873337.1, XP_011543386.1, XP_016873338.1, XP_011543382.1, XP_011543383.1, XP_016873339.1, XP_016873336.1, NP_001122092.1, XP_011543384.1, XP_016873335.1

ZINC - World Drugs

PAK1_HUMAN

Guide to Pharmacology - Targets

2133

OpenTargets

ENSG00000149269

ZINC - FDA approved

PAK1_HUMAN

ZINC - Substances

PAK1_HUMAN

ZINC - Biogenic

PAK1_HUMAN

ZINC target

Q13153

PRO

Q13153

GlyGen

Q13153

PDB

1ZSG, 4O0R, 4DAW, 5DEY, 4O0T, 1F3M, 1YHW, 4ZLO, 1YHV, 4ZY5, 4P90, 5DEW, 4ZY6, 4ZJI, 5IME, 5KBR, 2HY8, 4ZY4, 4ZJJ, 3FXZ, 2QME, 5KBQ, 6B16, 4EQC, 3Q4Z, 3DVP, 5DFP, 3Q52, 3FY0, 3Q53

ZINC - Investigational

PAK1_HUMAN

GeneCards

Q13153

HPA

ENSG00000149269-PAK1

Ensembl

ENSP00000348696, ENSP00000278568, ENST00000356341, ENST00000278568, ENSG00000149269

Pharos - Targets

Q13153

ZINC - Predictions - Purchasable

PAK1_HUMAN

HMDB Protein

HMDBP08499

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63000 RAC1	6	RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.976	27
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.945	12
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.944	15
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.88	10
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.778	4
UniProt:Q9Y2X7 GIT1	2	p-Y383-GIT1 [cytosol] (R-HSA-3928463) GIT1 [cytosol] (R-HSA-430326)	0.744	5
UniProt:P21127 CDK11B	1	CDK11B [cytosol] (R-HSA-380451)	0.69	4
UniProt:P63001 Rac1	7	Rac1 [endoplasmic reticulum membrane] (R-MMU-5672076) Rac1 [secretory granule membrane] (R-MMU-6804770) Rac1 [ficolin-1-rich granule membrane] (R-MMU-6804802) Rac1 [plasma membrane] (R-MMU-2316446) Rac1 [plasma membrane] (R-MMU-421093) Rac1 [cytosol] (R-MMU-442615) Rac1 [plasma membrane] (R-MMU-2316449)	0.688	3
UniProt:P60766 Cdc42	3	Cdc42 [endoplasmic reticulum membrane] (R-MMU-5672086) Cdc42 [cytosol] (R-MMU-442630) Cdc42 [plasma membrane] (R-MMU-448841)	0.688	3
UniProt:P63167 DYNLL1	6	DYNLL1 [ciliary tip] (R-HSA-5625335) DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [cilium] (R-HSA-5624863)	0.666	4
UniProt:Q15052 ARHGEF6	1	ARHGEF6 [cytosol] (R-HSA-195017)	0.659	4
UniProt:Q8N1N5 CRPAK			0.645	6
UniProt:Q13177 PAK2	11	PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653)	0.643	4
UniProt:P63000-1 RAC1			0.641	3
UniProt:Q92963 RIT1	1	RIT1 [plasma membrane] (R-HSA-187703)	0.619	4
UniProt:P53667 LIMK1	3	p-S,T508-LIMK1 [cytosol] (R-HSA-419610) p-T508-LIMK1 [cytosol] (R-HSA-399816) LIMK1 [cytosol] (R-HSA-397785)	0.619	5
UniProt:P62999	6	RAC1 [endoplasmic reticulum membrane] (R-CFA-5672076) RAC1 [secretory granule membrane] (R-CFA-6804770) RAC1 [ficolin-1-rich granule membrane] (R-CFA-6804802) RAC1 [plasma membrane] (R-CFA-2316446) RAC1 [cytosol] (R-CFA-442615) RAC1 [plasma membrane] (R-CFA-351141)	0.617	3
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.611	3
UniProt:Q7L0Q8 RHOU	4	p-Y254-RHOU [endosome membrane] (R-HSA-9726860) p-Y254-RHOU [plasma membrane] (R-HSA-9726857) RHOU [plasma membrane] (R-HSA-194914) RHOU [cytosol] (R-HSA-194901)	0.589	3
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.564	3
UniProt:Q5PP90 Q5PP90			0.558	2
UniProt:Q96EF9 ZHX1R			0.556	3
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.556	3
UniProt:Q9H892-2 TTC12			0.556	3
IntAct:EBI-25839738 CCSB			0.556	3
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:P11117 PPAL			0.556	3
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.556	3
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.556	3
UniProt:Q15759 MAPK11	4	p-T180,Y182-MAPK11 [cytosol] (R-HSA-171009) MAPK11 [cytosol] (R-HSA-170989) MAPK11 [nucleoplasm] (R-HSA-203790) p-T180,Y182-MAPK11 [nucleoplasm] (R-HSA-198741)	0.556	3
UniProt:O60830 TIMM17B	2	TIMM17B [mitochondrial intermembrane space] (R-HSA-1955371) TIMM17B [mitochondrial inner membrane] (R-HSA-1252138)	0.556	3
UniProt:P32243-2 OTX2			0.556	3
UniProt:Q8WZ73-3 Q8WZ733			0.556	3
UniProt:P35611 ADD1	3	ADD1(634-737) [cytosol] (R-HSA-202890) ADD1(1-633) [cytosol] (R-HSA-202891) ADD1 [cytosol] (R-HSA-201623)	0.556	3
UniProt:Q9NTN9-3 SEMA4G			0.556	3
IntAct:EBI-25839688 CCSB			0.556	3
UniProt:Q8N0Y2-2 ZNF444			0.556	3
UniProt:Q6NZ36-4 FAAP20			0.556	3
UniProt:Q9H0W9-3 C11ORF54			0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:O75558 STX11			0.556	3
IntAct:EBI-25835277 CCSB			0.556	3
UniProt:Q8TDR4 TCP1L			0.556	3
UniProt:Q9H4E5 RHOJ	1	RHOJ [plasma membrane] (R-HSA-3006725)	0.556	3
UniProt:Q96A04 TSACC			0.556	3
UniProt:O60506-4 SYNCRIP			0.556	3
UniProt:Q13322-4 GRB10			0.556	3
UniProt:Q8N490-3 PNKD			0.556	3
UniProt:Q9Y239 NOD1	1	NOD1 [cytosol] (R-HSA-168407)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P60953-2 CDC42			0.547	2
UniProt:Q15365 PCBP1	1	PCBP1 [nucleoplasm] (R-HSA-71919)	0.524	2
UniProt:Q05513-1 PRKCZ			0.499	5

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