Reactome | p-S144,T423-PAK1 [plasma membrane]

p-S144,T423-PAK1 [plasma membrane]

Stable Identifier

R-HSA-3928472

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

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External Reference Information

External Reference

UniProt:Q13153 PAK1

Gene Names

PAK1

Chain

initiator methionine:1, chain:2-545

Reference Genes

BioGPS Gene:5058 PAK1

COSMIC (genes):PAK1 PAK1

CTD Gene:5058 PAK1

dbSNP Gene:5058 PAK1

ENSEMBL:ENSG00000149269 PAK1

HGNC:8590 PAK1

KEGG Gene (Homo sapiens):5058 PAK1

Monarch:5058 PAK1

NCBI Gene:5058 PAK1

OMIM:602590 PAK1

UCSC:Q13153 PAK1

Reference Transcript

Other Identifiers

0004810181

04150+2.7.11.1

04151+2.7.11.1

04714+2.7.11.1

04926+2.7.11.1

05163+2.7.11.1

05165+2.7.11.1

05170+2.7.11.1

11720103_a_at

11720104_a_at

1557_at

1558_g_at

1565772_at

16742454

1F3M

1YHV

1YHW

1ZSG

209615_s_at

226507_at

230100_x_at

2HY8

2QME

3382862

3382863

3382864

3382865

3382866

3382867

3382869

3382871

3382873

3382874

3382876

3382878

3382879

3382881

3382884

3382886

3382891

3382893

3382895

3382896

3382900

3382909

3565

3DVP

3FXZ

3FY0

3Q4Z

3Q52

3Q53

43052_at

43053_g_at

47835_at

4DAW

4EQC

4O0R

4O0T

4P90

4ZJI

4ZJJ

4ZLO

4ZY4

4ZY5

4ZY6

5058

5312

5DEW

5DEY

5DFP

5IME

5KBQ

5KBR

60859_at

6B16

7950578

A0A024R5P0

A_23_P75989

A_33_P3288609

A_33_P3784253

AAA65441

AAC24716

AAC50590

AAI09300

AF071884

AP000486

AP003680

B3KNX7

BC109299

CAB005312

CCDS44687

CCDS8250

CH471076

E9PJF8

E9PKH9

E9PM17

E9PMP2

E9PQW5

E9PRP6

EAW75026

EAW75027

EAW75029

ENSG00000149269

ENSP00000278568

ENSP00000348696

ENST00000278568

ENST00000278568.8

ENST00000356341

ENST00000356341.7

EntrezGene:5058

EntrezGene:PAK1

g1256421_3p_a_at

GE59021

GE86276

GO:0000166

GO:0000902

GO:0001666

GO:0001726

GO:0001934

GO:0002223

GO:0002376

GO:0003674

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005518

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005911

GO:0005925

GO:0006338

GO:0006464

GO:0006468

GO:0006605

GO:0006810

GO:0006887

GO:0006915

GO:0006950

GO:0006974

GO:0007010

GO:0007155

GO:0007165

GO:0008150

GO:0008152

GO:0008219

GO:0008283

GO:0008284

GO:0010033

GO:0010763

GO:0014704

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0019899

GO:0019901

GO:0021549

GO:0022607

GO:0023014

GO:0030010

GO:0030018

GO:0030027

GO:0030054

GO:0030154

GO:0030335

GO:0030424

GO:0030425

GO:0031098

GO:0031116

GO:0031295

GO:0031532

GO:0031965

GO:0032147

GO:0032587

GO:0032869

GO:0032956

GO:0032991

GO:0033138

GO:0033148

GO:0038095

GO:0038096

GO:0040007

GO:0040011

GO:0042060

GO:0042995

GO:0043167

GO:0043226

GO:0043408

GO:0043507

GO:0045773

GO:0046628

GO:0046777

GO:0048012

GO:0048013

GO:0048365

GO:0048754

GO:0048812

GO:0048856

GO:0048870

GO:0050770

GO:0050852

GO:0051276

GO:0051496

GO:0060244

GO:0061052

GO:0065003

GO:0071437

GO:0090314

GO:1904707

GO:1904754

HGNC:8590

HPA003565

Hs.23295.0.A1_3p_at

Hs.329996.0.A1_3p_s_at

ILMN_1767365

IPR000095

IPR000719

IPR008271

IPR011009

IPR017441

IPR033923

IPR036936

MIM:602590

MIM:618158

NM_001128620

NM_002576

NP_001122092

NP_002567

PAK1

PAK1-201

PAK1-202

PF00069

PF00786

PH_hs_0003990

SM00220

SM00285

TC11002123.hg

TC11003261.hg

U24152

U24152_at

U51120

UPI000013DB7F

UPI000013ED74

XM_011545080

XM_011545081

XM_011545082

XM_011545083

XM_011545084

XM_017017846

XM_017017847

XM_017017848

XM_017017849

XM_017017850

XM_024448557

XM_024448558

XM_024448559

XM_024448560

XM_024448561

XM_024448562

XM_024448563

XM_024448564

XP_011543382

XP_011543383

XP_011543384

XP_011543385

XP_011543386

XP_016873335

XP_016873336

XP_016873337

XP_016873338

XP_016873339

XP_024304325

XP_024304326

XP_024304327

XP_024304328

XP_024304329

XP_024304330

XP_024304331

XP_024304332

Participant Of

hasComponent

RAC1-GTP:p-S144,T423-PAK1 [plasma membrane]

hasMember

p-PAK1/3, 2 [plasma membrane]

Other forms of this molecule

Active PAK1 [cytosol]

p-S144-PAK1 [cytosol]

PAK1 [plasma membrane]

PAK1 [cytosol]

p-S144,T423-PAK1 [cytosol]

Inferred To

phospho-p-S144,T423-PAK1 [plasma membrane] (Bos taurus)

phospho-p-S144,T423-PAK1 [plasma membrane] (Caenorhabditis elegans)

phospho-p-S144,T423-PAK1 [plasma membrane] (Canis familiaris)

phospho-p-S144,T423-PAK1 [plasma membrane] (Danio rerio)

phospho-p-S144,T423-PAK1 [plasma membrane] (Dictyostelium discoideum)

phospho-p-S144,T423-PAK1 [plasma membrane] (Drosophila melanogaster)

phospho-p-S144,T423-PAK1 [plasma membrane] (Gallus gallus)

phospho-p-S144,T423-PAK1 [plasma membrane] (Mus musculus)

phospho-p-S144,T423-PAK1 [plasma membrane] (Rattus norvegicus)

phospho-p-S144,T423-PAK1 [plasma membrane] (Sus scrofa)

phospho-p-S144,T423-PAK1 [plasma membrane] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 144

Coordinate

144

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 423

Coordinate

423

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_011543382.1, XP_016873337.1, XP_016873338.1, XP_011543386.1, NP_002567.3, XP_016873339.1, NP_001122092.1, XP_011543385.1, XP_016873336.1, XP_011543383.1, XP_016873335.1, XP_011543384.1

ZINC - World Drugs

PAK1_HUMAN

OpenTargets

ENSG00000149269

ZINC - FDA approved

PAK1_HUMAN

ZINC - Substances

PAK1_HUMAN

ZINC target

Q13153

ZINC - Biogenic

PAK1_HUMAN

PRO

Q13153

PDB

3Q53, 5DFP, 4O0T, 4ZY4, 1ZSG, 4ZLO, 1YHW, 2HY8, 3FY0, 3Q4Z, 4O0R, 3Q52, 3FXZ, 1F3M, 4P90, 4ZJJ, 4DAW, 4ZJI, 3DVP, 2QME, 1YHV, 5KBR, 5DEY, 5KBQ, 5IME, 4ZY6, 6B16, 5DEW, 4EQC, 4ZY5

ZINC - Investigational

PAK1_HUMAN

GeneCards

Q13153

ZINC - Predictions - Purchasable

PAK1_HUMAN

HMDB Protein

HMDBP08499

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.976	27
UniProt:P60953 CDC42	3	CDC42 [plasma membrane] (R-HSA-449545) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630)	0.944	15
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.935	9
GTP [ChEBI:15996]	13	GTP [early endosome membrane] (R-ALL-2130170) GTP [cilium] (R-ALL-5617813) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [extracellular region] (R-ALL-114626) GTP [Golgi lumen] (R-ALL-8851242) GTP [endocytic vesicle lumen] (R-ALL-8851508) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [mitochondrial matrix] (R-ALL-113573) GTP [Golgi membrane] (R-ALL-1806221) GTP [nucleoplasm] (R-ALL-113571) GTP [cytosol] (R-ALL-29438)	0.778	4
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.766	6
UniProt:P21127 CDK11B	1	CDK11B [cytosol] (R-HSA-380451)	0.69	4
UniProt:P63001 Rac1	7	RAC1 [ficolin-1-rich granule membrane] (R-MMU-6804802) RAC1 [endoplasmic reticulum membrane] (R-MMU-5672076) RAC1 [secretory granule membrane] (R-MMU-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-MMU-2316446) Rac1 [plasma membrane] (R-MMU-2316449) RAC1 [cytosol] (R-MMU-442615) Rac1 [plasma membrane] (R-MMU-421093)	0.688	3
UniProt:P60766 Cdc42	3	Cdc42 [plasma membrane] (R-MMU-448841) CDC42 [endoplasmic reticulum membrane] (R-MMU-5672086) CDC42 [cytosol] (R-MMU-442630)	0.688	3
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.669	3
UniProt:Q8N1N5 CRPAK			0.645	6
UniProt:P63000-1 RAC1			0.641	3
UniProt:P53667 LIMK1	3	p-T508-LIMK1 [cytosol] (R-HSA-399816) LIMK1 [cytosol] (R-HSA-397785) p-S,T508-LIMK1 [cytosol] (R-HSA-419610)	0.619	5
UniProt:P62999 RAC1			0.617	3
UniProt:Q7L0Q8 RHOU	2	RHOU [cytosol] (R-HSA-194901) RHOU [plasma membrane] (R-HSA-194914)	0.589	3
UniProt:Q5PP90 Q5PP90			0.558	2
UniProt:Q15052 ARHGEF6	1	ARHGEF6 [cytosol] (R-HSA-195017)	0.547	2
UniProt:P60953-2 CDC42			0.547	2
UniProt:Q15365 PCBP1	1	PCBP1 [nucleoplasm] (R-HSA-71919)	0.524	2
UniProt:Q05513-1 PRKCZ			0.499	5