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ROCK phosphorylates LIMK1,2
Stable Identifier
R-HSA-3928577
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
ROCK phosphorylates LIMK1,2 (Homo sapiens)
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Rho-associated kinases (ROCKs) contribute to the formation of actin filaments by inactivating cofilin via phosphorylation of LIM domain kinases (LIMKs). ROCKs phosphorylate LIMK1 at Thr508 and LIMK2 at Thr505, enhancing the ability of LIMKs to phosphorylate cofilin. LIMK1 has been shown to be involved in dendritic spine development, as LIMK1 KO mice fail to form morphologically mature dendritic spines (Meng et al. 2002).
Participants
Input
ATP [cytosol]
LIM Kinases [cytosol]
(Homo sapiens)
Output
ADP [cytosol]
p-LIMK [cytosol]
(Homo sapiens)
Participates
as an event of
EPHB-mediated forward signaling (Homo sapiens)
Catalyst Activity
protein serine/threonine kinase activity of RHOA:GTP:ROCK1,ROCK2 [plasma membrane]
Physical Entity
RHOA:GTP:ROCK1,ROCK2 [plasma membrane]
(Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
ROCK1 phosphorylates LIMK2 (rat) (Homo sapiens)
Authored
Garapati, P V (2013-07-23)
Reviewed
Ip, NY (2014-05-19)
Created
Garapati, P V (2013-07-22)
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