Reactome | SFKs phosphorylate VAV2,3

SFKs phosphorylate VAV2,3

Stable Identifier

R-HSA-3928604

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Upon ephrin (EFN)-mediated stimulation, proto-oncogene vav (VAV) is transiently tyrosine phosphorylated and activated in neurons, possibly by Src family kinases (SFKs). VAV2 and VAV3 are phosphorylated on Y172 and Y173 respectively in the acidic domain and this phosphorylation disrupts the inhibitory interaction of the acidic domain with the DH domain (Cowan et al. 2005, Marignani & Carpenter 2001).

Literature References

PubMed ID	Title	Journal	Year
15848800	Vav family GEFs link activated Ephs to endocytosis and axon guidance Sahin, M, Greenberg, ME, Gao, S, Griffith, EC, Lin, MZ, Shao, YR, Shamah, SM, Cowan, CW, Brugge, JS, Greer, PL	Neuron	2005
11448999	Vav2 is required for cell spreading Carpenter, CL, Marignani, PA	J. Cell Biol.	2001