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SFKs phosphorylate VAV2,3

Stable Identifier
R-HSA-3928604
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Upon ephrin (EFN)-mediated stimulation, proto-oncogene vav (VAV) is transiently tyrosine phosphorylated and activated in neurons, possibly by Src family kinases (SFKs). VAV2 and VAV3 are phosphorylated on Y172 and Y173 respectively in the acidic domain and this phosphorylation disrupts the inhibitory interaction of the acidic domain with the DH domain (Cowan et al. 2005, Marignani & Carpenter 2001).

Literature References
PubMed ID Title Journal Year
11448999 Vav2 is required for cell spreading J. Cell Biol. 2001
15848800 Vav family GEFs link activated Ephs to endocytosis and axon guidance Neuron 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane]
Physical Entity
Activity
Orthologous Events