Reactome: A Curated Pathway Database

SFKs phosphorylate VAV2,3

Stable Identifier
R-HSA-3928604
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Upon ephrin (EFN)-mediated stimulation, proto-oncogene vav (VAV) is transiently tyrosine phosphorylated and activated in neurons, possibly by Src family kinases (SFKs). VAV2 and VAV3 are phosphorylated on Y172 and Y173 respectively in the acidic domain and this phosphorylation disrupts the inhibitory interaction of the acidic domain with the DH domain (Cowan et al. 2005, Marignani & Carpenter 2001).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] protein tyrosine kinase activity (0004713)
Orthologous Events