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p-EPHs bind VAV2,3

Stable Identifier
R-HSA-3928607
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The alternate method required for the initial EPH receptor:ephrin (EPH:EFN) adhesion into repulsion is by RAC-dependent endocytosis, an atypical endocytic mechanism by which the EPH:EFN complex and surrounding plasma membrane are internalized into one cell. Proto-oncogene vavs (VAVs) provide a molecular link between activated EPHs and RAC-dependent endocytosis. Upon the activation of EPH receptor, VAV proteins are recruited to the intracellular domain of EPHs and become transiently activated. Cowan et al. showed that VAV2 interacts with either EPHA4 or EPHB2, indicating that VAV can bind to either EPHA or EPHB subclass receptors. Autophosphorylated juxta-membrane tyrosines (Y596 and Y602 of human EPHA4) provide docking sites for VAV proteins (Cowan et al. 2007).

Literature References
PubMed ID Title Journal Year
15848800 Vav family GEFs link activated Ephs to endocytosis and axon guidance Neuron 2005
Participants
Participant Of
Orthologous Events