EFNB:GRB4 binds GIT1

Stable Identifier
R-HSA-3928614
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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EFNB:GRB4 binds GIT1
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G-protein-coupled receptor kinase-interacting protein 1 (GIT1) is enriched in both presynaptic and postsynaptic terminals and after phosphorylation is targeted to the synapse by binding to cytoplasmic protein GRB4 (NCK2 aka GRB4). GRB4 binds by its SH2 domain to Tyr392 (Human Tyr383) in the synaptic localization domain (SLD) of GIT1. GIT1 acts as an adapter protein by providing docking site for beta-PIX (PAK interacting exchange factor) and serves to localize Rac activity (Segura et al. 2007, Zhang et al. 2003).

Literature References
PubMed ID Title Journal Year
12695502 Synapse formation is regulated by the signaling adaptor GIT1

Zhang, H, Webb, DJ, Asmussen, H, Horwitz, AF

J. Cell Biol. 2003
17310244 Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation

Segura, I, Essmann, CL, Weinges, S, Acker-Palmer, A

Nat. Neurosci. 2007
Participants
Input
Output
Entity On Other Cell
Participant Of
hasEvent
Orthologous Events
EFNB:GRB4 binds GIT1 (Bos taurus)
EFNB:GRB4 binds GIT1 (Caenorhabditis elegans)
EFNB:GRB4 binds GIT1 (Canis familiaris)
EFNB:GRB4 binds GIT1 (Danio rerio)
EFNB:GRB4 binds GIT1 (Gallus gallus)
EFNB:GRB4 binds GIT1 (Mus musculus)
EFNB:GRB4 binds GIT1 (Rattus norvegicus)
EFNB:GRB4 binds GIT1 (Sus scrofa)
EFNB:GRB4 binds GIT1 (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)