GIT1 binds bPIX

Stable Identifier
R-HSA-3928631
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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p-21-activated kinase (PAK) interacting exchange factor (beta-PIX, bPIX aka ARHGEF7) is a Rac guanine nucleotide exchange factor that acts downstream of GIT1 to affect spine morphology and synapse formation. Endogenous bPIX is present in hippocampal neurons and is targeted to the synapses by binding to GIT1. bPIX serves as an exchange factor for Rac and a binding protein for a Rac effector, PAK (Zhang et al. 2003).

Literature References
PubMed ID Title Journal Year
12695502 Synapse formation is regulated by the signaling adaptor GIT1

Zhang, H, Webb, DJ, Asmussen, H, Horwitz, AF

J. Cell Biol. 2003
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