p-EFNB binds GRB4

Stable Identifier
R-HSA-3928639
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Unlike EPH receptors, ephrinBs (EFNBs) do not possess intrinsic catalytic activity and thus rely on the recruitment of signaling molecules to signal. Phosphorylated ephrinB (p-EFNB) provides docking site for the SH2/SH3 domain-containing adapter protein cytoplasmic protein NCK2 (NCK2 aka GRB4) (Cowan & Henkemeyer 2001). GRB4 is able to bind to phosphotyrosines in EFNBs through their SH2 domains and 'PxxP' motifs through their SH3 domains. It has been postulated that GRB4 acts as a bridge between EFNBs and G protein-coupled receptor kinase interacting protein (GIT) 1 and Rac at synapses (Segura et al. 2007).
Literature References
PubMed ID Title Journal Year
17310244 Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation

Acker-Palmer, A, Essmann, CL, Weinges, S, Segura, I

Nat. Neurosci. 2007
11557983 The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals

Henkemeyer, M, Cowan, CA

Nature 2001
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!